INT184310

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.81
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
ligament 1
tendon 1
Comp (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 41 96.84 Very High Very High Very High
Inflammation 15 91.52 High High
cytokine 4 90.48 High High
rheumatoid arthritis 25 5.00 Very Low Very Low Very Low
Osteoarthritis 12 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 68 100.00 Very High Very High Very High
INFLAMMATION 14 91.52 High High
Immunization 5 86.40 High High
Tendinopathy 15 81.44 Quite High
Hypercalcemia 8 79.48 Quite High
Muscle Disease 87 78.36 Quite High
Stress 72 58.76 Quite High
Cicatrix 9 58.72 Quite High
Osteoporosis 16 50.00 Quite Low
Apoptosis 9 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of COMP were increased in arthritic mice but were not affected by hormonal status (Fig. 4c).


Neg (not) Regulation (affected) of COMP associated with arthritis
1) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.26 Pain Relevance 0.41
The detrimental effect of COMP mutations on collagen fibrillogenesis has been previously demonstrated in vitro (51).
Regulation (effect) of COMP
2) Confidence 0.39 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.12 Pain Relevance 0
We have shown that Comp is expressed in murine tendon and ligament by a variety of techniques, and that the localization of mutant COMP was not altered in mutant tissues.
Neg (not) Regulation (altered) of COMP in ligament
3) Confidence 0.23 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.22 Pain Relevance 0
We have shown that Comp is expressed in murine tendon and ligament by a variety of techniques, and that the localization of mutant COMP was not altered in mutant tissues.
Neg (not) Regulation (altered) of COMP in tendon
4) Confidence 0.08 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.22 Pain Relevance 0

General Comments

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