INT184313

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.23
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
joint 2
cartilage 2
Comp (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 254 99.96 Very High Very High Very High
Inflammation 84 96.36 Very High Very High Very High
cytokine 27 87.28 High High
agonist 30 76.88 Quite High
rheumatoid arthritis 104 50.00 Quite Low
Inflammatory response 4 50.00 Quite Low
chemokine 8 25.92 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 49 99.96 Very High Very High Very High
Arthritis 289 99.84 Very High Very High Very High
INFLAMMATION 83 96.36 Very High Very High Very High
Disease 59 89.12 High High
Immunization 29 86.40 High High
Hypercalcemia 17 79.48 Quite High
Osteoporosis 56 63.84 Quite High
Hypersensitivity 26 60.64 Quite High
Rheumatoid Arthritis 104 50.00 Quite Low
Necrosis 5 45.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found increased serum COMP levels in all arthritic mice, irrespective of the estrogen level, indicating a lack of cartilage protection by endogenous ovarian hormones.
Positive_regulation (increased) of COMP in cartilage associated with arthritis
1) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 0.74 Pain Relevance 0.13
Serum levels of COMP were increased in arthritic mice but were not affected by hormonal status (Fig. 4c).


Positive_regulation (increased) of COMP associated with arthritis
2) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.23 Pain Relevance 0.40
The serum levels of COMP (cartilage oligomeric matrix protein) are elevated in arthritis due to increased destruction of joint cartilage.
Positive_regulation (elevated) of cartilage oligomeric matrix protein in joint associated with arthritis
3) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009959 Disease Relevance 0.60 Pain Relevance 0.14
The serum levels of COMP (cartilage oligomeric matrix protein) are elevated in arthritis due to increased destruction of joint cartilage.
Positive_regulation (elevated) of COMP in joint associated with arthritis
4) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009959 Disease Relevance 0.60 Pain Relevance 0.14
In CIA, serum COMP levels are increased due to enhanced cartilage destruction.
Positive_regulation (increased) of serum COMP in cartilage associated with arthritis
5) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.05 Pain Relevance 0.44

General Comments

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