INT184314

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2008
Negated 4
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 7.11
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bglap) cytoplasm (Bglap)
Anatomy Link Frequency
osteoblast 2
CII 2
Bglap (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 90 100.00 Very High Very High Very High
cytokine 24 99.72 Very High Very High Very High
Arthritis 38 90.56 High High
Inflammation 15 63.60 Quite High
fibrosis 5 29.16 Quite Low
rheumatoid arthritis 25 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 155 100.00 Very High Very High Very High
Pancreatitis 90 100.00 Very High Very High Very High
Immunization 5 99.64 Very High Very High Very High
Pancreatic Cancer 145 99.40 Very High Very High Very High
Osteoporosis 28 98.32 Very High Very High Very High
Cancer 77 95.60 Very High Very High Very High
Hypercalcemia 18 92.36 High High
Arthritis 65 90.56 High High
Metastasis 25 82.64 Quite High
INFLAMMATION 14 63.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other cytokines demonstrated no significant effects on BGLAP expression in the tested pancreatic cancer cells (data not shown).
Neg (no) Regulation (effects) of Gene_expression (expression) of BGLAP associated with pancreatic cancer and cytokine
1) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.70 Pain Relevance 0.09
Since BGLAP was expressed in pancreatic cancer tissues and cells, various growth factors that might be involved in pancreatic carcinogenesis were examined for their effect on BGLAP expression.
Spec (examined) Regulation (effect) of Gene_expression (expression) of BGLAP associated with pancreatic cancer
2) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.06 Pain Relevance 0.12
In addition, BGLAP protein was detected in the cell culture supernatants of the same four cell lines by EIA, where the range of BGLAP expression was 3.4 to 4 ng/ml (figure 5B).
Regulation (range) of Gene_expression (expression) of BGLAP
3) Confidence 0.43 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.27 Pain Relevance 0.16
There was no significant difference between CP and PDAC serum BGLAP levels.
Neg (no) Regulation (difference) of Gene_expression (levels) of PDAC serum BGLAP associated with adenocarcinoma and chronic pancreatitis
4) Confidence 0.38 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.36 Pain Relevance 0.31
Although osteocalcin bioactivity is regulated by at least two gene products within the osteoblast, Esp and ?
Regulation (regulated) of Gene_expression (bioactivity) of osteocalcin in osteoblast associated with osteoporosis
5) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.25 Pain Relevance 0
The other growth factors and cytokines exhibited no effects on BGLAP expression in the tested pancreatic cancer cells.
Neg (no) Regulation (effects) of Gene_expression (expression) of BGLAP associated with pancreatic cancer and cytokine
6) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.24 Pain Relevance 0.09
Immunization with CII did not affect the levels of osteocalcin.
Neg (not) Regulation (affect) of Gene_expression (levels) of osteocalcin in CII associated with immunization
7) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.22 Pain Relevance 0.38

General Comments

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