INT184339

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.86
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fcgrt)
Anatomy Link Frequency
Mouse 1
endothelial cells 1
gut 1
Fcgrt (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 76 88.64 High High
rheumatoid arthritis 33 71.36 Quite High
Arthritis 40 66.56 Quite High
cytokine 14 45.24 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 390 99.88 Very High Very High Very High
Hypersensitivity 370 99.44 Very High Very High Very High
Acute Disease 12 98.08 Very High Very High Very High
Immunization 92 97.36 Very High Very High Very High
INFLAMMATION 73 88.64 High High
Rhinitis 19 88.12 High High
Aging 5 87.72 High High
Measles 6 84.64 Quite High
Peritonitis 1 75.56 Quite High
Arthus Reaction 8 74.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these and other data presented in this report, we were able to show that expression of FcRn was important for offspring to acquire sufficient levels of allergen-specific IgG1 from the breast milk of allergic mothers to prevent allergen-specific IgE responses.
Gene_expression (expression) of FcRn associated with hypersensitivity
1) Confidence 0.68 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.75 Pain Relevance 0
We demonstrated that levels of OVA-specific IgG1 absorbed from the gut into the circulation of breastfed offspring was determined by offspring FcRn expression.
Spec (determined) Gene_expression (expression) of FcRn in gut
2) Confidence 0.68 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.96 Pain Relevance 0
Mouse FcRn has been shown to be highly promiscuous as it binds Fc of different species including bovine IgG, whereas human FcRn binds less well to IgG from this species [27].
Gene_expression (promiscuous) of FcRn in Mouse
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964324 Disease Relevance 0.61 Pain Relevance 0
However, in the previous study, while the TNP-specific IgG1 injected into pregnant mice was present in the serum of breastfed FcRn+/- neonates (10-20 ?
Gene_expression (present) of FcRn
4) Confidence 0.52 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.26 Pain Relevance 0
This is supported by data from offspring nursed by allergic mothers where few, if any, FcRn-sufficient offspring produced allergen-specific IgE at 7 days after the second intraperitoneal immunization (data not shown).
Gene_expression (produced) of FcRn associated with immunization and hypersensitivity
5) Confidence 0.52 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.52 Pain Relevance 0
Similarly, during acute disease following 7 days of OVA aerosol challenge, comparable levels of OVA-specific IgG1 and IgE were present in the serum from B6AAD and FcRn-/-AAD mice (Figure 1B and 1C).
Gene_expression (present) of FcRn associated with acute disease and disease
6) Confidence 0.52 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.78 Pain Relevance 0
The particular receptor responsible for maintaining IgG titers in blood is the intracellular Fc receptor (FcRn) that is abundantly expressed in endothelial cells.
Gene_expression (expressed) of FcRn in endothelial cells
7) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.99 Pain Relevance 0.23
FcRn expression was a major factor in determining how breastfed offspring of allergic mothers acquired levels of systemic allergen-specific IgG1 sufficient to inhibit allergic sensitization in this model.



Gene_expression (expression) of FcRn associated with hypersensitivity
8) Confidence 0.46 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2914046 Disease Relevance 1.00 Pain Relevance 0.04

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