INT184341

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.66
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4b) extracellular region (C4b)
Anatomy Link Frequency
erythrocytes 1
brain 1
C4b (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 100.00 Very High Very High Very High
rheumatoid arthritis 34 97.84 Very High Very High Very High
Inflammation 94 88.48 High High
TRP channel 50 79.28 Quite High
Arthritis 48 74.52 Quite High
ischemia 12 70.32 Quite High
cytokine 23 52.24 Quite High
tolerance 8 39.40 Quite Low
antagonist 1 25.76 Quite Low
Inflammatory response 6 20.28 Low Low
Disease Link Frequency Relevance Heat
Depression 8 100.00 Very High Very High Very High
Sprains And Strains 76 99.52 Very High Very High Very High
Autoimmune Disease 46 99.04 Very High Very High Very High
Recurrence 2 98.64 Very High Very High Very High
Targeted Disruption 86 98.52 Very High Very High Very High
Rheumatoid Arthritis 34 97.84 Very High Very High Very High
Apoptosis 81 97.64 Very High Very High Very High
Disease 170 96.72 Very High Very High Very High
Systemic Lupus Erythematosus 134 94.92 High High
Hepatitis 2 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum from the mice had depressed C4 levels and increased hemolytic activity using antibody-coated sheep erythrocytes.
Negative_regulation (depressed) of C4 in erythrocytes
1) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.54 Pain Relevance 0.03
It therefore seems more probable that the development of autoimmunity in MRL mice is in part related to a functional deficiency in C4, similar to that seen in humans with deficiencies in early classical pathway components such as C1q, C2, and C4.
Negative_regulation (deficiencies) of C4 associated with autoimmune disease
2) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.55 Pain Relevance 0
At 20 weeks of age, both C3 and C4 levels in KO MRL mice were equivalent to levels in CTRL MRL serum (Figure 4).
Negative_regulation (equivalent) of C4
3) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.16 Pain Relevance 0
In comparison with C57BL/6 mice, MRL/lpr mice had depressed C4 levels as early as 3 weeks of age.
Negative_regulation (depressed) of C4
4) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212569 Disease Relevance 0.76 Pain Relevance 0.04
Although it is possible that the reduced levels of C4 in the MRL strain limit the intrinsic capacity of the classical pathway to generate C3b, there are data to suggest that amplification of C3b generation via the alternative pathway is required for immune complex clearance [50].
Negative_regulation (reduced) of C4 associated with sprains and strains
5) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.29 Pain Relevance 0
C4 levels were also equivalent at 8 weeks of age.
Negative_regulation (equivalent) of C4
6) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.16 Pain Relevance 0
It therefore seems more probable that the development of autoimmunity in MRL mice is in part related to a functional deficiency in C4, similar to that seen in humans with deficiencies in early classical pathway components such as C1q, C2, and C4.
Negative_regulation (deficiency) of C4 associated with autoimmune disease
7) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.44 Pain Relevance 0
The total hemolytic complement, C3, and C4 are drastically reduced in SF relative to the total protein in patients with RA.
Negative_regulation (reduced) of C4 associated with rheumatoid arthritis
8) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.36 Pain Relevance 0.42
Riccio and coworkers [12] also showed a high prevalence of TRPC1, C4, C5, and C7 in the CNS, i.e. a much stronger expression in all brain regions than in peripheral tissues.
Negative_regulation (prevalence) of C4 in brain
9) Confidence 0.17 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.04
Systemic complement activation, however, marked by depression of serum C3 and C4 levels and peripheral deposition of these proteins, is associated with increased disease activity [2,3].
Negative_regulation (depression) of C4 associated with depression and disease
10) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 1.35 Pain Relevance 0.11
In this small study, a C1-INH dose-dependent reduction in activation fragments of C4 was shown.
Negative_regulation (reduction) of C4
11) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.89 Pain Relevance 0.10
Laboratory workup revealed mild C4 deficiency and an undetectable IgE level (Table 1).
Negative_regulation (deficiency) of C4
12) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 1.16 Pain Relevance 0

General Comments

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