INT184345

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.56
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tsg101) endosome (Tsg101) transport (Tsg101)
cytoplasm (Tsg101) protein modification process (Tsg101) nucleolus (Tsg101)
Tsg101 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 40 99.24 Very High Very High Very High
rheumatoid arthritis 33 92.64 High High
Inflammation 27 76.96 Quite High
cytokine 8 68.08 Quite High
Kinase C 32 5.00 Very Low Very Low Very Low
imagery 21 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 42 99.24 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 600 99.00 Very High Very High Very High
Choroideremia 166 97.04 Very High Very High Very High
Rheumatoid Arthritis 33 92.64 High High
Targeted Disruption 8 92.64 High High
Muscular Dystrophy 2 90.40 High High
Adhesions 3 87.16 High High
Cancer 28 87.04 High High
INFLAMMATION 38 76.96 Quite High
Disease 35 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Gene_expression (expression) of CC2 associated with choroideremia
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.77 Pain Relevance 0.06
Overexpression of full length TSG101 has been shown to inhibit ESCRT-I function and block EGF-induced EGFR downregulation [14,32].
Gene_expression (Overexpression) of TSG101
2) Confidence 0.33 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.14 Pain Relevance 0
For TSG101 knockdown experiments, COS-1 cells were seeded to approximately 30% density and transfected the next day with 25 to 50 nM TSG101 or LacZ siRNA and 0.5 to 1 ?
Gene_expression (transfected) of TSG101
3) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.19 Pain Relevance 0
g plasmid DNA using Lipofectamine 2000 according to the manufacturer's recommendations. 24 hours later, the cells were transfected again with 25 to 50 nM TSG101 or LacZ siRNA.
Gene_expression (transfected) of TSG101
4) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.27 Pain Relevance 0
Given that HIV-1 Gag competes with Hrs for TSG101 in vitro [48], and that overexpression of TSG101-binding regions of Hrs inhibits HIV-1 release [49], we hypothesized that expression of Gag would compete for TSG101 binding and function in vivo.
Gene_expression (overexpression) of TSG101-binding associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.46 Pain Relevance 0
Gag expressing cells, like TSG101-depleted and Vps4E228Q overexpressing cells, exhibited an initial slowdown in the rate of CD4 degradation, which was completely overcome upon prolonged exposure to PMA (Fig. 5A).
Gene_expression (overexpressing) of TSG101
6) Confidence 0.26 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.24 Pain Relevance 0
COS-1 cells overexpressing TSG101 also exhibited attenuated HA-CXCR4 degradation (Fig. 1A).
Gene_expression (overexpressing) of TSG101
7) Confidence 0.26 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.21 Pain Relevance 0
For TSG101 knockdown experiments, COS-1 cells were seeded to approximately 30% density and transfected the next day with 25 to 50 nM TSG101 or LacZ siRNA and 0.5 to 1 ?
Gene_expression (experiments) of TSG101
8) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.09 Pain Relevance 0
Addition of siRNA directed against TSG101 resulted in 80% knockdown of endogenous TSG101 levels (Fig. 1B).
Gene_expression (levels) of TSG101
9) Confidence 0.25 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0
Similar observations were seen with SWR mice that, in spite of expressing the I-Aq susceptibility gene, are resistant to CIA because of a genetic deficiency in producing C5 [15].
Gene_expression (expressing) of I-Aq susceptibility gene associated with arthritis
10) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.19 Pain Relevance 0.51

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