INT184346

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.83
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cfb) peptidase activity (Cfb) extracellular space (Cfb)
extracellular region (Cfb)
Anatomy Link Frequency
cleavage 2
neutrophils 2
Cfb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 47 98.70 Very High Very High Very High
rheumatoid arthritis 45 78.32 Quite High
Arthritis 40 72.96 Quite High
Inflammatory response 8 45.68 Quite Low
Pain 3 43.80 Quite Low
ischemia 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 54 98.70 Very High Very High Very High
Rheumatoid Arthritis 45 78.32 Quite High
Arthritis 42 72.96 Quite High
Death 4 68.36 Quite High
Synovitis 3 68.24 Quite High
Disease 55 48.68 Quite Low
Pruritus 2 44.24 Quite Low
Pain 3 43.80 Quite Low
Increased Venous Pressure Under Development 3 39.36 Quite Low
Targeted Disruption 8 19.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The chemotactic effects of C5a-C5aR ligation then attracts neutrophils to sites of inflammation to produce properdin, which, upon binding to C3b-IgG complexes, enhances the association with factor B, leading to stabilization of the alternative pathway C3 convertase and amplification of the alternative pathway C3 consumption.
Positive_regulation (enhances) of factor B Binding (association) of in neutrophils associated with inflammation
1) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.70 Pain Relevance 0.25
Properdin binds to surface-bound C3b and increases its ability to interact with factor B [17].
Positive_regulation (increases) of factor B Binding (interact) of
2) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Factor B interacts with C3b, leading to its cleavage by factor D and the formation of the C3 convertase (C3bBb).
Positive_regulation (leading) of convertase Binding (formation) of in cleavage
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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