INT184354

Context Info Confidence 0.26 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.44 Pain Relevance 0.34

plasma membrane (Fcgrt)

Fcgrt (Mus musculus)

Pain Link Frequency Relevance Heat addiction 2 99.40 Arthritis 80 97.76 rheumatoid arthritis 66 33.76 Inflammation 54 33.76 Inflammatory response 8 28.80 cytokine 4 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Disease 50 98.84 Arthritis 84 97.76 Autoimmune Disease 16 91.64 Idiopathic Thrombocytopenic Purpura 2 88.80 Hypergammaglobulinemia 2 71.24 Rheumatoid Arthritis 66 33.76 INFLAMMATION 60 33.76 Peritonitis 2 30.68 Arthus Reaction 16 29.72 Targeted Disruption 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, transferring large amounts of sera from sick mice could override the protective effect of FcRn deficiency, suggesting a dependence of disease induction on antibody concentration.

Negative_regulation (deficiency) of FcRn associated with addiction and disease

1) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.72 Pain Relevance 0.18

Recently Akilesh and colleagues [49] crossed FcRn deficient mice with the genetically determined K/B × N arthritis model.

Negative_regulation (crossed) of FcRn associated with arthritis

2) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.72 Pain Relevance 0.15

General Comments

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