INT184355

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.60
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fcgrt)
Anatomy Link Frequency
synovial fluid 1
Mouse 1
lumen 1
Fcgrt (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 40 96.36 Very High Very High Very High
rheumatoid arthritis 33 93.44 High High
Inflammation 44 78.96 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 42 96.36 Very High Very High Very High
Rheumatoid Arthritis 33 93.44 High High
Aging 5 92.08 High High
Cancer 2 90.32 High High
Necrosis 2 90.08 High High
Disease 150 87.60 High High
Hypersensitivity 126 85.12 High High
INFLAMMATION 45 78.96 Quite High
Death 7 63.64 Quite High
Weight Loss 7 63.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The explanation for the diversity in results from different laboratories is not obvious, but could be due to different routes of injection - intraperitoneal versus intravenous, or structural features of the injected monoclonal antibodies tested that contribute to their inherent strengths of interaction with FcRn.
FcRn Binding (interaction) of
1) Confidence 0.42 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.17 Pain Relevance 0
Mouse FcRn has been shown to be highly promiscuous as it binds Fc of different species including bovine IgG, whereas human FcRn binds less well to IgG from this species [27].
FcRn Binding (binds) of in Mouse
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964324 Disease Relevance 0.62 Pain Relevance 0
As compared to IgG acquired via intravenous injection, it is possible that ingested IgG selected by FcRn for absorption from the gut lumen has a higher binding affinity for FcRn systemically, and thereby has increased protection from catabolism.
FcRn Binding (binding) of in lumen
3) Confidence 0.29 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0 Pain Relevance 0
receptor; FcRn = intracellular Fc receptor; GPI = glucose-6-phosphate isomerase; IC = immune complex; IL = interleukin; IVIG = intravenous therapy with high doses of normal IgG; RA = rheumatoid arthritis; RF = rheumatoid factor; SF = synovial fluid; TNF = tumor necrosis factor.


FcRn Binding (receptor) of in synovial fluid associated with necrosis, cancer and rheumatoid arthritis
4) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.81 Pain Relevance 0.23

General Comments

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