INT184359

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.48
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C5ar1) plasma membrane (C5ar1) signal transducer activity (C5ar1)
Anatomy Link Frequency
mast cells 2
macrophages 1
leukocytes 1
F4/80 1
neutrophils 1
C5ar1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 165 98.32 Very High Very High Very High
Inflammation 146 98.14 Very High Very High Very High
Arthritis 200 96.40 Very High Very High Very High
Inflammatory stimuli 4 11.60 Low Low
Inflammatory response 26 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 126 98.96 Very High Very High Very High
Rheumatoid Arthritis 165 98.32 Very High Very High Very High
INFLAMMATION 171 98.14 Very High Very High Very High
Arthritis 210 96.40 Very High Very High Very High
Systemic Lupus Erythematosus 10 81.60 Quite High
Synovitis 15 80.56 Quite High
Increased Venous Pressure Under Development 5 79.20 Quite High
Immunization 5 78.48 Quite High
Renal Disease 5 78.24 Quite High
Targeted Disruption 20 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, included in this set were GPCRs such as Emr1 (F4/80), C3aR, C5aR, Ccrl2 and Ccr2 that are known to be either macrophage-specific or highly expressed by macrophages [8-12], thus validating our approach.
Gene_expression (expressed) of C5aR in F4/80
1) Confidence 0.55 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
Expression of C5aR was also noted in synovial mast cells in RA joints [25], and mast cells are essential in arthritis induced by anti-GPI sera [26].
Gene_expression (Expression) of C5aR in mast cells associated with rheumatoid arthritis and arthritis
2) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.86 Pain Relevance 0.36
These proteins also modulate the inflammatory process by the complement receptors CR1/CD35, CR2/CD21, CR3/ CD11b-CD18, CR4/CD11c-CD18 and C5aR, expressed on leukocytes [13-17].
Gene_expression (expressed) of C5aR in leukocytes associated with inflammation
3) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.06 Pain Relevance 0.26
C6-deficient mice also developed disease, suggesting that the late complement activation step (complement lysis by the membrane attack complex) is not involved in disease activity, but rather that the C5a interaction with C5aR expressed on many cell types such as neutrophils, macrophages and mast cells might be involved.
Gene_expression (expressed) of C5aR in neutrophils associated with disease
4) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.19 Pain Relevance 0.24
C6-deficient mice also developed disease, suggesting that the late complement activation step (complement lysis by the membrane attack complex) is not involved in disease activity, but rather that the C5a interaction with C5aR expressed on many cell types such as neutrophils, macrophages and mast cells might be involved.
Gene_expression (expressed) of C5aR in mast cells associated with disease
5) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.19 Pain Relevance 0.24
C6-deficient mice also developed disease, suggesting that the late complement activation step (complement lysis by the membrane attack complex) is not involved in disease activity, but rather that the C5a interaction with C5aR expressed on many cell types such as neutrophils, macrophages and mast cells might be involved.
Gene_expression (expressed) of C5aR in macrophages associated with disease
6) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.19 Pain Relevance 0.24

General Comments

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