INT184365

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 13.86
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
skin 2
body 2
joint 1
cardiomyocytes 1
fat 1
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
rheumatoid arthritis 122 99.20 Very High Very High Very High
tolerance 126 98.18 Very High Very High Very High
Arthritis 157 98.16 Very High Very High Very High
Eae 8 96.64 Very High Very High Very High
ischemia 41 90.60 High High
Inflammation 182 82.72 Quite High
Central nervous system 11 65.04 Quite High
Multiple sclerosis 2 63.76 Quite High
tetrodotoxin 1 60.88 Quite High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Targeted Disruption 72 99.88 Very High Very High Very High
Membranoproliferative Glomerulonephritis 9 99.88 Very High Very High Very High
Sprains And Strains 103 99.52 Very High Very High Very High
Disease 432 99.40 Very High Very High Very High
Rheumatoid Arthritis 122 99.20 Very High Very High Very High
Arthritis 167 98.16 Very High Very High Very High
Myocardial Infarction 147 97.70 Very High Very High Very High
Apoptosis 40 97.64 Very High Very High Very High
Disease Progression 10 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 2Histopathology of ankle joints, and deposition of C3 in joint tissue.
Negative_regulation (deposition) of C3 in joint
1) Confidence 0.43 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.26 Pain Relevance 0.12
Interestingly, we also show that deficiency of C3 results in a rapid rejection of male skin grafts, similar to that observed with C1q deficiency.
Negative_regulation (deficiency) of C3 in skin
2) Confidence 0.34 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.08 Pain Relevance 0.22
We first evaluated whether the lack of C1q or C3 influenced the rejection of male skin grafts.
Spec (whether) Negative_regulation (lack) of C3 in skin
3) Confidence 0.34 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.19 Pain Relevance 0.10
Similarly, C3 deficiency associates with a decreased production of IFN-?
Negative_regulation (deficiency) of C3
4) Confidence 0.34 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.28 Pain Relevance 0.16
Most of these studies have used pharmacological approaches which led to complete "shut-down" of the complement system at the level where the three different activation pathways merge by inhibiting the C3 convertases (Fig. 1) [20,21,25,26].
Negative_regulation (inhibiting) of C3
5) Confidence 0.34 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 1.08 Pain Relevance 0.07
The total hemolytic complement, C3, and C4 are drastically reduced in SF relative to the total protein in patients with RA.
Negative_regulation (reduced) of C3 associated with rheumatoid arthritis
6) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.37 Pain Relevance 0.42
Tolerance to male grafts following intranasal administration of HY peptide also fails to occur when C3 is absent.
Negative_regulation (absent) of C3 associated with tolerance
7) Confidence 0.30 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.07 Pain Relevance 0.21
At 20 weeks of age, both C3 and C4 levels in KO MRL mice were equivalent to levels in CTRL MRL serum (Figure 4).
Negative_regulation (equivalent) of C3
8) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.17 Pain Relevance 0
In CCR2-deficient or C3 inhibitor-overexpressing mice, however, an increase in A?
Negative_regulation (inhibitor) of C3
9) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.13 Pain Relevance 0.06
In CCR2-deficient or C3 inhibitor-overexpressing mice, however, an increase in A?
Negative_regulation (deficient) of C3
10) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.14 Pain Relevance 0.06
Systemic complement activation, however, marked by depression of serum C3 and C4 levels and peripheral deposition of these proteins, is associated with increased disease activity [2,3].
Negative_regulation (depression) of C3 associated with depression and disease
11) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 1.35 Pain Relevance 0.11
Whole body bone mineral density (BMD) was significantly reduced in the C3.Dll1tm1Gos/+ animals compared to their wild-type littermates (Figure 5A).
Negative_regulation (reduced) of C3 in body
12) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.23 Pain Relevance 0
Whole body bone mineral content (BMC) was significantly reduced in C3.Dll1tm1Gos/+ females, and a similar tendency was observed in male animals (Figure 5C).
Negative_regulation (reduced) of C3 in body
13) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.24 Pain Relevance 0
However, progeny mice of crosses between K/B × N and knockout mice deficient for either complement factor B, C3, C5 or C5aR were found to be completely resistant to arthritis.
Negative_regulation (deficient) of C3 associated with targeted disruption and arthritis
14) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.27 Pain Relevance 0.33
Also comparable to the changes observed in Dll1tm1Gos/+ animals, the systolic, diastolic and mean arterial pressures were significantly increased, and the pulse significantly decreased in C3.Dll1C413Y/+ animals.
Negative_regulation (decreased) of C3
15) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.08 Pain Relevance 0.09
The fat mass was also significantly decreased in C3.Dll1C413Y/+ animals.
Negative_regulation (decreased) of C3 in fat
16) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.09 Pain Relevance 0.07
Initial indications that activation of the complement cascade might have a role in RA was shown by the observation that rats depleted of complement C3 by using cobra venom factor are resistant to CIA [13].
Negative_regulation (depleted) of C3 associated with rheumatoid arthritis and arthritis
17) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.30 Pain Relevance 0.57
Stevens et al. (2007) showed that mice lacking complement components C1q and C3 have deficits in developmental synaptic refinement in the visual system.
Negative_regulation (lacking) of C3 in visual system
18) Confidence 0.19 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.09 Pain Relevance 0.09
Mice deficient in FH develop Type II MPGN with deposition of C3 in the capillary walls (Pickering et al 2002).
Negative_regulation (deposition) of C3 in capillary associated with membranoproliferative glomerulonephritis
19) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.74 Pain Relevance 0.07
In a rat model of MI, C1-INH suppressed C3 mRNA expression and protein synthesis, while in cultured rat cardiomyocytes, C1-INH blocked deposition of C3 (Fu et al 2006b).
Negative_regulation (deposition) of C3 in cardiomyocytes associated with myocardial infarction
20) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.04 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox