INT184370

Context Info Confidence 0.66 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.76 Pain Relevance 0.63

plasma membrane (Fcgrt)

Anatomy Link Frequency vesicle 1 Fcgrt (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 62 97.92 rheumatoid arthritis 66 90.64 Arthritis 80 85.84 Inflammatory response 8 5.00 cytokine 6 5.00 Pain 2 5.00 addiction 2 5.00 ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Disease 110 98.28 INFLAMMATION 67 97.92 Peritonitis 2 94.84 Arthus Reaction 16 93.88 Rheumatoid Arthritis 66 90.64 Arthritis 84 85.84 Hypergammaglobulinemia 2 81.28 Hypersensitivity 65 76.88 Autoimmune Disease 18 67.60 Immunization 17 61.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, FcRn-/- offspring displayed significantly reduced OVA-specific IgG1 serum concentrations (< 6 ?

Localization (offspring) of FcRn

1) Confidence 0.66 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.39 Pain Relevance 0

Maintaining autoantibody titers through FcRn-mediated recycling

Localization (recycling) of FcRn

2) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.39 Pain Relevance 0.41

The FcRn binds pinocytosed IgG only in the acidic environment of the endosome and releases intact IgG when its transport vesicle is redirected to the neutral pH of the cell surface.

Localization (releases) of FcRn in vesicle

3) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.98 Pain Relevance 0.22

General Comments

This test has worked.