INT184406

Context Info Confidence 0.00 First Reported 2005 Last Reported 2005 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.40

plasma membrane (HLA-DRB1, HLA-E) endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)

HLA-DRB1 (Homo sapiens) HLA-E (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 30 97.08 Arthritis 78 76.08 Inflammation 26 41.60 spondylitis 1 32.92 cytokine 7 5.00 tolerance 7 5.00 antagonist 5 5.00 Multiple sclerosis 4 5.00 Pain 3 5.00 chemokine 3 5.00

Disease Link Frequency Relevance Heat Disease 26 97.94 Rheumatoid Arthritis 30 97.08 Immunization 6 77.88 Arthritis 90 76.08 Sprains And Strains 8 44.84 INFLAMMATION 22 41.60 Low Back Pain 1 32.92 Multiple Sclerosis 13 31.52 Body Weight 5 5.00 Hyperplasia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Whereas RA susceptibility, more precisely the disease severity, in the human population maps to the major histocompatibility complex (MHC) class II alleles HLA-DR1 to HLA-DR4, no apparent association with the MHC class II region has been observed in rhesus monkeys thus far.

HLA-DR1 Neg (no) Binding (association) of MHC associated with rheumatoid arthritis and disease

1) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.03 Pain Relevance 0.40

General Comments

This test has worked.