INT184407

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.26
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1, HLA-DRB4) Golgi apparatus (HLA-DRB1, HLA-DRB4) endoplasmic reticulum (HLA-DRB1, HLA-DRB4)
plasma membrane (HLA-DRB1, HLA-DRB4) signal transduction (HLA-DRB4)
HLA-DRB1 (Homo sapiens)
HLA-DRB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 30 97.08 Very High Very High Very High
Arthritis 78 76.08 Quite High
Inflammation 26 41.60 Quite Low
spondylitis 1 32.92 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 41 97.94 Very High Very High Very High
Rheumatoid Arthritis 30 97.08 Very High Very High Very High
Dengue Hemorrhagic Fever 139 83.52 Quite High
Infection 44 78.96 Quite High
Immunization 6 77.88 Quite High
Arthritis 90 76.08 Quite High
Dengue 21 56.92 Quite High
Hepatitis B Virus Infection 1 56.24 Quite High
Hepatitis 2 55.72 Quite High
Hepatitis C Virus Infection 2 55.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possibility of primary disease-protective association with DRB4*01 (encoding DR53 sero-specificity) remains to be examined because of DRB4*01 haplotypic association with DRB1*07, *04 and *0901 was found in all populations which have been studied [42], although neither DRB1*07 or DRB1*04 exhibited difference in frequency in our samples.


DRB1 Spec (examined) Binding (association) of DRB4 associated with disease
1) Confidence 0.09 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.23 Pain Relevance 0
Whereas RA susceptibility, more precisely the disease severity, in the human population maps to the major histocompatibility complex (MHC) class II alleles HLA-DR1 to HLA-DR4, no apparent association with the MHC class II region has been observed in rhesus monkeys thus far.
HLA-DR1 Neg (no) Binding (association) of HLA-DR4 associated with rheumatoid arthritis and disease
2) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.03 Pain Relevance 0.40

General Comments

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