INT184415

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.32
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 110 96.28 Very High Very High Very High
Angina 11 83.04 Quite High
ischemia 5 75.72 Quite High
Pain 3 73.48 Quite High
Arthritis 78 72.92 Quite High
cytokine 17 20.72 Low Low
Inflammatory marker 16 20.24 Low Low
rheumatoid arthritis 30 6.28 Low Low
tolerance 7 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 35 99.84 Very High Very High Very High
Natriuresis 1 99.24 Very High Very High Very High
Cardiovascular Disease 4 99.08 Very High Very High Very High
Atherosclerosis 17 98.00 Very High Very High Very High
Myocardial Infarction 18 96.60 Very High Very High Very High
INFLAMMATION 126 96.28 Very High Very High Very High
Death 5 93.88 High High
Cancer 9 93.48 High High
Disease 40 93.20 High High
Arthritis 90 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic levels of both CRP and IL-6 have been identified as important
Regulation (important) of Positive_regulation (levels) of CRP
1) Confidence 0.43 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 1.77 Pain Relevance 0.26
These apparently contradictory findings may be explained by hypothesizing a strong influence of troponin values on CRP increase in ACS.16

B-Type Natriuretic Peptide as Additional Risk Marker

Spec (hypothesizing) Regulation (influence) of Positive_regulation (increase) of CRP associated with natriuresis and acute coronary syndrome
2) Confidence 0.23 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.96 Pain Relevance 0.23
The production of the serum protein albumin is affected by the induction of acute-phase proteins such as CRP (Fig. 2, top panel).
Regulation (affected) of Positive_regulation (induction) of CRP
3) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.18 Pain Relevance 0.23
This SNP is in high LD with a SNP in the IL6 regulatory region (-572 G > C; rs1800795) that was shown to functionally influence IL-6 expression and increase CRP levels [25]; a potential glucocorticoid receptor element exists nearby.
Regulation (influence) of Positive_regulation (increase) of CRP
4) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC3006374 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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