INT184418

Context Info Confidence 0.26 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 15 Total Number 15 Disease Relevance 5.47 Pain Relevance 0.87

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)

Anatomy Link Frequency CD86 2 cartilage 2 apoptotic cells 2 GOPC (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 78 100.00 ischemia 22 100.00 agonist 48 99.46 rheumatoid arthritis 35 94.96 Inflammation 115 87.16 antagonist 37 79.12 Pain 33 75.20 cva 3 67.92 Somatostatin 5 57.36 metalloproteinase 2 50.00

Disease Link Frequency Relevance Heat Arthritis 90 100.00 Cv Unclassified Under Development 16 100.00 Apoptosis 97 98.60 Death 65 97.80 Hyperplasia 5 97.12 Cancer 93 96.12 Rheumatoid Arthritis 35 94.96 Toxicity 27 91.68 INFLAMMATION 94 87.16 Pituitary Cancer 11 86.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, shunting can reduce the depolarization caused by excitatory input (Fig. 3), which reduces firing rate (Fig. 4A), but it also shortens ?

Negative_regulation (reduce) of Positive_regulation (caused) of Fig

1) Confidence 0.26 Published 2006 Journal Mol Pain Section Body Doc Link PMC1624821 Disease Relevance 0 Pain Relevance 0

But the interesting observation in Fig. 6b is the presence of a minimal total treatment time at PTs of 70, 65 and 60°C for HRs of 200, 100 and 50°C min?

Negative_regulation (presence) of Positive_regulation (observation) of Fig

2) Confidence 0.17 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.80 Pain Relevance 0

Licorice inhibited caspase-3 activation (Fig. 6) and reduced the population of apoptotic cells (Fig. 4) in a dose dependent manner.

Negative_regulation (inhibited) of Positive_regulation (activation) of Fig in apoptotic cells associated with apoptosis

3) Confidence 0.13 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2396482 Disease Relevance 1.48 Pain Relevance 0

Concomitantly, the LPO activity also decreased with an increase in the GSH levels in the subjects (Fig. 3e and f).

Negative_regulation (decreased) of Positive_regulation (increase) of Fig

4) Confidence 0.11 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.31 Pain Relevance 0

Moreover, the prostacyclin analogue Cicaprost significantly impaired Rho activation (Fig. 9C) and cofilin phosphorylation (Fig. 9D) in 1° h.AoSMCs pre-treated with siRNATP?

Negative_regulation (impaired) of Positive_regulation (activation) of Fig

5) Confidence 0.10 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0

Consistent with this, the specific PGD2 receptor (DP) agonist BW245C also significantly impaired RhoA activation (Fig. 7C) and cofilin phosphorylation in 1° h.AoSMCs.

Negative_regulation (impaired) of Positive_regulation (activation) of Fig associated with agonist

6) Confidence 0.10 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09

Next, we evaluated the ability of ruthenium red to inhibit noxious cold activation of TRPA1 (Fig. 2E).

Negative_regulation (inhibit) of Positive_regulation (activation) of Fig

7) Confidence 0.09 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.07

Indeed, in our case series only two patients had an increased mean TSH concentration (Fig. 2), although the other patients should have had suppressed TSH levels due to elevated T4 (T3) concentrations.

Negative_regulation (suppressed) of Positive_regulation (increased) of Fig

8) Confidence 0.09 Published 2008 Journal Pituitary Section Body Doc Link PMC2712623 Disease Relevance 0.69 Pain Relevance 0.03

Consistently, pretreatment with JNK inhibitor SP600125 also decreased JNK activation (Fig. 5B, lane 4).

Negative_regulation (decreased) of Positive_regulation (activation) of Fig

9) Confidence 0.08 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.20 Pain Relevance 0

Consistent with the gene expression data, curcumin pretreatment of HIMECs inhibited COX-2 protein expression at 1 µM, with increasing effect at 10 µM curcumin, while 20 µM curcumin completely abolished COX-2 expression following VEGF activation (fig 2B).

Negative_regulation (abolished) of Positive_regulation (activation) of fig

10) Confidence 0.06 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0 Pain Relevance 0

As demonstrated by flow cytometry analysis, Gal-4 significantly inhibited expression of the co-stimulatory molecules CD80 and CD86 expression on PBMC (Fig. 3A).

Negative_regulation (inhibited) of Positive_regulation (molecules) of Fig in CD86

11) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0

The addition of DHT to C-33 cells decreased PAcP expression and increased Her2 phosphorylation (Fig. 3A).

Negative_regulation (decreased) of Positive_regulation (increased) of Fig

12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

M NS398 demonstrated inhibition of COX-2 expression following VEGF activation (fig 2C).

Negative_regulation (inhibition) of Positive_regulation (activation) of fig

13) Confidence 0.04 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0 Pain Relevance 0

These preceded the dramatic destruction of cartilage and bone in advanced CIA (Fig. 3, bottom left).

Negative_regulation (preceded) of Positive_regulation (advanced) of Fig in cartilage associated with arthritis

14) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.46 Pain Relevance 0.51

The same treatment regimen with intra-peritoneal minocycline also significantly reduced the ischemia-induced increase in MMP total protein concentration (Fig. 3) (n = 6 for PBS and 8 for minocycline treated groups, p < 0.038 for MMP-9 and p < 0.018 for MMP-2).

Negative_regulation (reduced) of Positive_regulation (increase) of Fig associated with ischemia

15) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.53 Pain Relevance 0.17

General Comments

This test has worked.