INT184433

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.48
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts4) extracellular space (Adamts4) extracellular region (Adamts4)
proteinaceous extracellular matrix (Adamts4)
Anatomy Link Frequency
cleavage 1
articular cartilage 1
Adamts4 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 32 96.00 Very High Very High Very High
Inflammation 16 95.60 Very High Very High Very High
Osteoarthritis 44 89.84 High High
cytokine 8 82.56 Quite High
metalloproteinase 44 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 97.56 Very High Very High Very High
Arthritis 44 96.00 Very High Very High Very High
Osteoarthritis 44 89.84 High High
Thrombotic Thrombocytopenic Purpura 8 80.76 Quite High
INFLAMMATION 12 64.96 Quite High
Alzheimer's Dementia 4 63.04 Quite High
Necrosis 8 52.00 Quite High
Cancer 8 51.64 Quite High
Adenocarcinoma 4 39.68 Quite Low
Congenital Anomalies 16 32.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together these studies suggest that, at least in these mouse models, ADAMTS-5 is primarily responsible for the increased aggrecanase activity.
Positive_regulation (increased) of aggrecanase
1) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 1.01 Pain Relevance 0.29
, despite the marked upregulation of aggrecanase activity [73-75].
Positive_regulation (upregulation) of aggrecanase
2) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.29 Pain Relevance 0.13
A recent study of truncated recombinant forms of ADAMTS-4 indicated that the presence of the CRD was required for maximal aggrecanase activity, whereas the inclusion of the spacer region prevented cleavage of aggrecan at the IGD site [27].
Positive_regulation (required) of aggrecanase in cleavage
3) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.08 Pain Relevance 0
Furthermore, aggrecanase activity was inducible in articular cartilage explants from wild-type and ADAMTS-4 knockout mice but not from ADAMTS-5 knockout littermates [34-36].
Positive_regulation (inducible) of aggrecanase in articular cartilage associated with targeted disruption
4) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 1.10 Pain Relevance 0.32

General Comments

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