INT184434

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.95
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts1) extracellular region (Adamts1) proteinaceous extracellular matrix (Adamts1)
Anatomy Link Frequency
cleavage 1
neural 1
Adamts1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 48 99.72 Very High Very High Very High
Hippocampus 12 57.12 Quite High
Central nervous system 20 51.08 Quite High
fibrosis 7 41.36 Quite Low
Osteoarthritis 22 5.00 Very Low Very Low Very Low
Arthritis 17 5.00 Very Low Very Low Very Low
Deafferentation 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 7 99.28 Very High Very High Very High
Ectopia Lentis 2 94.12 High High
Syndrome 54 92.28 High High
Disease 11 91.36 High High
Cleidocranial Dysplasia 32 84.08 Quite High
Glaucoma 1 82.24 Quite High
Dislocations 1 79.88 Quite High
Injury 9 76.00 Quite High
Targeted Disruption 21 72.64 Quite High
Brain Injury 4 62.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the ability to localize and quantitate the ADAMTS specific, proteolytic product of brevican provides a means to indirectly estimate ADAMTS activity during times of neural plasticity and synaptogenesis.
Localization (localize) of ADAMTS in neural
1) Confidence 0.63 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0.21 Pain Relevance 0.14
In contrast to the absence of a defined substrate for the MMPs, a selective ADAMTS-derived, brevican fragment was localized to the OML after seizure-induced lesion in the rat [16].
Localization (localized) of ADAMTS-derived associated with convulsion and metalloproteinase
2) Confidence 0.55 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0.30 Pain Relevance 0.28
The pro-domain of all ADAMTS proteinases contains at least one furin cleavage consensus motif; it is therefore generally believed that the zymogen forms of ADAMTS proteinases are cleaved intracellularly and that secreted proteins are in the mature form.
Localization (secreted) of ADAMTS in cleavage
3) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0 Pain Relevance 0
Secreted ADAMTS proteinases can undergo additional processing at their C-terminal end.
Localization (Secreted) of ADAMTS
4) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.09 Pain Relevance 0
This superfamily contains secreted ADAMTS metalloproteases as well as ADAMTS-like proteins, which are not proteases, but secreted glycoproteins whose domain structure resembles the C-terminal ancillary domains of ADAMTS proteases [26].
Localization (secreted) of ADAMTS
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941456 Disease Relevance 1.35 Pain Relevance 0

General Comments

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