INT184435

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.64
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 61 99.12 Very High Very High Very High
Inflammation 56 98.72 Very High Very High Very High
ischemia 4 96.72 Very High Very High Very High
Central nervous system 34 88.76 High High
Hippocampus 4 50.08 Quite High
Inflammatory response 6 48.76 Quite Low
long-term potentiation 3 45.00 Quite Low
cINOD 13 5.00 Very Low Very Low Very Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
metalloproteinase 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 72 100.00 Very High Very High Very High
Targeted Disruption 22 100.00 Very High Very High Very High
INFLAMMATION 66 98.72 Very High Very High Very High
Injury 36 98.08 Very High Very High Very High
Cv Unclassified Under Development 4 96.72 Very High Very High Very High
Brain Injury 9 84.40 Quite High
Dementia 2 69.60 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 29 68.80 Quite High
Alzheimer's Dementia 63 68.48 Quite High
Neurodegenerative Disease 9 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-inhibitor (0,1 mM) before incubation with IL-1?
Negative_regulation (inhibitor) of IL-1 Binding (incubation) of
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952629 Disease Relevance 0 Pain Relevance 0
Conversely, ischemic damage is greatly reduced by knockout of IL-1?
Negative_regulation (reduced) of IL-1 Binding (knockout) of associated with targeted disruption
2) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.48 Pain Relevance 0.26
Chlorhexidine (CHX) caused a less marked increase in HSV susceptibility and only statistically insignificant trends in Il-1?
Negative_regulation (caused) of Il-1 Binding (trends) of associated with cold sores
3) Confidence 0.05 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.99 Pain Relevance 0.62
A recent study of ADAMTS-4 suggests that the increase in aggrecanase activity observed after treatment with IL-1?
Negative_regulation (observed) of IL-1 Binding (treatment) of
4) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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