INT184436

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 6
Total Number 16
Disease Relevance 9.53
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts1) extracellular region (Adamts1) proteinaceous extracellular matrix (Adamts1)
Anatomy Link Frequency
blood vessel 10
cleavage 4
hippocampus 4
dentate gyrus 2
tendon 2
Adamts1 (Mus musculus)
Pain Link Frequency Relevance Heat
Deafferentation 15 99.72 Very High Very High Very High
cytokine 17 99.08 Very High Very High Very High
Hippocampus 18 98.08 Very High Very High Very High
metalloproteinase 107 97.88 Very High Very High Very High
Mechanotransduction 1 97.28 Very High Very High Very High
Glutamate 3 87.20 High High
Osteoarthritis 33 84.56 Quite High
Central nervous system 30 79.92 Quite High
Inflammation 12 73.04 Quite High
Pain 20 22.08 Low Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 12 99.64 Very High Very High Very High
Cancer 997 99.60 Very High Very High Very High
Growth Problems 3 97.28 Very High Very High Very High
Prostate Cancer 225 96.20 Very High Very High Very High
Syndrome 9 95.76 Very High Very High Very High
Adenocarcinoma 3 89.20 High High
Necrosis 7 88.80 High High
Metastasis 54 86.68 High High
Osteoarthritis 33 84.56 Quite High
Vascular Tissue Neoplasms 9 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, modified ADAMTS1 expression did not affect the cleavage of TSP1 in LNCaP or LNCaP-19 tumors.
Regulation (modified) of Gene_expression (expression) of ADAMTS1 in cleavage associated with cancer
1) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.97 Pain Relevance 0
The blood vessel morphology was similarly affected by ADAMTS1 expression in LNCaP-19 tumors.
Regulation (affected) of Gene_expression (expression) of ADAMTS1 in blood vessel associated with cancer
2) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.15 Pain Relevance 0
Since TSP1 is a potent angiogenesis inhibitor, this may explain why the MVD in the tumor xenografts was not affected by altered levels of ADAMTS1.
Neg (not) Regulation (affected) of Gene_expression (levels) of ADAMTS1 associated with cancer
3) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.90 Pain Relevance 0
However, modified ADAMTS1 expression did not affect the cleavage of TSP1 in LNCaP or LNCaP-19 tumors.
Neg (not) Regulation (affect) of Gene_expression (expression) of ADAMTS1 in cleavage associated with cancer
4) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.98 Pain Relevance 0
Modified expression of ADAMTS1 in LNCaP and LNCaP-19 cells
Regulation (Modified) of Gene_expression (expression) of ADAMTS1
5) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.35 Pain Relevance 0
However, modified expression of ADAMTS1 did not influence the degree of pericyte coverage, indicating that altered vessel stabilization by pericytes is not involved in the altered blood vessel morphology observed.
Neg (not) Regulation (influence) of Gene_expression (expression) of ADAMTS1 in blood vessel
6) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.84 Pain Relevance 0
Regulation of ADAMTS expression, structure and activity
Regulation (Regulation) of Gene_expression (expression) of ADAMTS
7) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.71 Pain Relevance 0.04
Significant changes were observed in the abundance of the different isoforms of brevican including the expression of the C-terminally-truncated ADAMTS-derived brevican fragment during plastic events in the hippocampus.
Regulation (truncated) of Gene_expression (expression) of ADAMTS-derived in hippocampus associated with hippocampus
8) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0 Pain Relevance 0.05
Significant changes were observed in the abundance of the different isoforms of brevican including the expression of the C-terminally-truncated ADAMTS-derived brevican fragment during plastic events in the hippocampus.
Regulation (abundance) of Gene_expression (expression) of ADAMTS-derived in hippocampus associated with hippocampus
9) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0 Pain Relevance 0.05
Functions of ADAMTS proteins
Regulation (Functions) of Gene_expression (proteins) of ADAMTS
10) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.18 Pain Relevance 0.04
We report that modified expression of ADAMTS1 resulted in markedly changed blood vessel morphology and TSP1 levels in the tumor xenografts, while MVD and pericyte coverage was unaffected.
Regulation (modified) of Gene_expression (expression) of ADAMTS1 in blood vessel associated with cancer
11) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.07 Pain Relevance 0
In conclusion, modified ADAMTS1 expression resulted in markedly changed blood vessel morphology and altered TSP1 levels in the tumors.
Regulation (modified) of Gene_expression (expression) of ADAMTS1 in blood vessel associated with cancer
12) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.14 Pain Relevance 0
Roles of the ADAMTS family in connective tissues
Regulation (Roles) of Gene_expression (family) of ADAMTS in connective tissues
13) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.21 Pain Relevance 0.11
Interestingly, we found that modified expression of ADAMTS1 markedly altered the blood vessel morphology in these tumor xenografts, while the number of blood vessels was unaffected.
Regulation (modified) of Gene_expression (expression) of ADAMTS1 in blood vessels associated with cancer
14) Confidence 0.23 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.03 Pain Relevance 0
The purpose of these experiments was to determine whether the production of brevican or the ADAMTS-cleaved fragments of brevican were altered after deafferentation and reinnervation of the dentate gyrus via entorhinal cortex lesion (ECL).


Spec (whether) Regulation (altered) of Spec (whether) Gene_expression (production) of ADAMTS in dentate gyrus associated with deafferentation
15) Confidence 0.21 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1199600 Disease Relevance 0 Pain Relevance 0.18
Indeed, mechanical loading of tendon is a potential regulatory mechanism for metalloproteinase gene expression (Banes et al., 1999; Lavagnino et al., 2003; Lee et al., 2005) that might complement the regulation of ADAMTS expression by growth factors and cytokines.
Spec (might) Regulation (regulation) of Gene_expression (expression) of ADAMTS in tendon associated with metalloproteinase and cytokine
16) Confidence 0.03 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.15

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