INT184439

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts1) extracellular region (Adamts1) proteinaceous extracellular matrix (Adamts1)
Anatomy Link Frequency
cleavage 1
Adamts1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 33 99.84 Very High Very High Very High
Arthritis 24 83.68 Quite High
Inflammation 12 40.88 Quite Low
Glutamate 3 29.60 Quite Low
metalloproteinase 33 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 33 99.84 Very High Very High Very High
Arthritis 33 83.68 Quite High
Thrombotic Thrombocytopenic Purpura 6 77.76 Quite High
Targeted Disruption 27 75.52 Quite High
Disease 6 74.64 Quite High
Congenital Anomalies 12 70.48 Quite High
Joint Instability 3 57.12 Quite High
Syndrome 9 49.48 Quite Low
Necrosis 6 10.52 Low Low
Cancer 6 10.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADAMTS-4 and -5 have been implicated as the aggrecanases involved in aggrecan degradation in osteoarthritis (OA) on the basis of mRNA and protein expression [3].
Protein_catabolism (degradation) of ADAMTS associated with osteoarthritis
1) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.66 Pain Relevance 0.23
The cleavage of ADAMTS-1 and -4 proteins within the CRD-spacer region reduces the affinity of both for heparin, suggesting that the spacer region influences these interactions [83,84].
Protein_catabolism (cleavage) of ADAMTS-1 in cleavage
2) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0 Pain Relevance 0
ADAMTS-13 cleaves the large multimeric von Willebrand factor (vWF) precursor to generate vWF of optimal size for proper coagulation [20,61,62].
Protein_catabolism (cleaves) of ADAMTS
3) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.41 Pain Relevance 0

General Comments

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