INT184443

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts1) extracellular region (Adamts1) proteinaceous extracellular matrix (Adamts1)
Anatomy Link Frequency
cleavage 2
Adamts1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 17 5.00 Very Low Very Low Very Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 222 100.00 Very High Very High Very High
Prostate Cancer 50 77.12 Quite High
Thrombotic Thrombocytopenic Purpura 2 49.28 Quite Low
Disease 2 46.44 Quite Low
Metastasis 12 5.00 Very Low Very Low Very Low
Arthritis 11 5.00 Very Low Very Low Very Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, upregulation of ADAMTS1 inhibited tumor growth of LNCaP-19, as evidenced by delayed tumor establishment.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of ADAMTS1 associated with cancer
1) Confidence 0.37 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2894797 Disease Relevance 1.12 Pain Relevance 0
Real-time RT-PCR and western blotting analysis revealed significantly decreased mRNA and protein levels of ADAMTS1 in LA- tumors compared to LC tumors (Figure 1A, B, C) and an obvious increase in ADAMTS1 expression in L19A + tumors compared to L19C tumors (Figure 1D, E, F).
Negative_regulation (decreased) of Positive_regulation (increase) of ADAMTS1 associated with cancer
2) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.00 Pain Relevance 0
The cleavage of ADAMTS-1 and -4 proteins within the CRD-spacer region reduces the affinity of both for heparin, suggesting that the spacer region influences these interactions [83,84].
Negative_regulation (reduces) of Positive_regulation (cleavage) of ADAMTS-1 in cleavage
3) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0 Pain Relevance 0

General Comments

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