INT184447

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts2) extracellular region (Adamts2) proteinaceous extracellular matrix (Adamts2)
Anatomy Link Frequency
tendon 1
Adamts2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 98.24 Very High Very High Very High
Osteoarthritis 22 89.92 High High
metalloproteinase 22 86.56 High High
Arthritis 16 14.96 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 22 89.92 High High
Arthritis 22 75.68 Quite High
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Thrombotic Thrombocytopenic Purpura 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the TIMP family, papilin, a protein with homology to the ancillary domains of ADAMTS proteins, is a non-competitive inhibitor of ADAMTS-2 [92].
Negative_regulation (inhibitor) of ADAMTS-2
1) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.15 Pain Relevance 0.08
A lower expression level of ADAMTS-5 and higher levels of ADAMTS-2, -12, -14 and -17 were observed in chronic painful tendon.
Negative_regulation (level) of ADAMTS-2 in tendon associated with pain
2) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.39 Pain Relevance 0.39

General Comments

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