INT184449

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 5.05
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts1) extracellular region (Adamts1) proteinaceous extracellular matrix (Adamts1)
Anatomy Link Frequency
blood vessel 1
connective tissues 1
hippocampus 1
Adamts1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 6 98.08 Very High Very High Very High
Arthritis 32 96.84 Very High Very High Very High
metalloproteinase 74 94.48 High High
Inflammation 16 93.68 High High
cytokine 19 89.96 High High
Pain 22 61.68 Quite High
Mechanotransduction 1 53.32 Quite High
Osteoarthritis 44 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 339 99.96 Very High Very High Very High
Arthritis 45 96.84 Very High Very High Very High
INFLAMMATION 12 93.68 High High
Alzheimer's Dementia 4 91.76 High High
Necrosis 9 80.72 Quite High
Thrombotic Thrombocytopenic Purpura 8 71.20 Quite High
Adenocarcinoma 4 68.40 Quite High
Tendinopathy 10 61.04 Quite High
Congenital Anomalies 16 60.84 Quite High
Prostate Cancer 75 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, increased levels of ADAMTS1 in LNCaP-19 resulted in markedly slower tumor establishment.
Regulation (resulted) of ADAMTS1 associated with cancer
1) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.81 Pain Relevance 0
Thus, the ADAMTS1-mediated effect on TSP1 levels could be a possible mechanism responsible for the switch in blood vessel morphology observed.
Spec (possible) Regulation (responsible) of ADAMTS1 in blood vessel
2) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.71 Pain Relevance 0
Decreased levels of ADAMTS1 did not affect tumor take of androgen-dependent LNCaP cells (Figure 2A), but strongly inhibited tumor growth rate.
Neg (not) Regulation (affect) of ADAMTS1 associated with cancer
3) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.37 Pain Relevance 0
Significant changes were observed in the abundance of the different isoforms of brevican including the expression of the C-terminally-truncated ADAMTS-derived brevican fragment during plastic events in the hippocampus.
Regulation (truncated) of ADAMTS-derived in hippocampus associated with hippocampus
4) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0 Pain Relevance 0.05
has been shown for ADAMTS-4 but not ADAMTS-5 [71], indicating that gene expression of these aggrecanases might be differentially regulated.
Spec (might) Regulation (regulated) of ADAMTS
5) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.76 Pain Relevance 0.22
The purpose of this review is to summarise the structure, function and regulation of the entire ADAMTS group of proteinases and to emphasise areas of potential relevance with regard to the homeostasis and pathology of connective tissues.


Regulation (regulation) of ADAMTS in connective tissues
6) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.10 Pain Relevance 0.12
ADAMTS levels and activities are regulated at multiple levels through the control of gene expression, mRNA splicing, protein processing and inhibition by TIMP (tissue inhibitor of metalloproteinases).
Regulation (regulated) of ADAMTS associated with metalloproteinase
7) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175049 Disease Relevance 0.17 Pain Relevance 0.18
These processing events also alter the activities of these proteins; for example, they reduce the angioinibitory capacity of ADAMTS-1 and alter the activity of ADAMTS-4 against aggrecan [83,84].
Regulation (alter) of ADAMTS
8) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.07 Pain Relevance 0
Studies using explant and cell cultures from other tissues have shown increased aggrecanase activity under conditions where ADAMTS mRNA and/or protein levels are not altered (Caterson et al., 2000; Flannery et al., 2000; Yaminishi et al., 2002; Pratta et al., 2003; Patwari et al., 2005), indicating that both the translation of the mRNA and the processing of the ADAMTS proenzymes are subject to regulation.
Neg (not) Regulation (altered) of ADAMTS
9) Confidence 0.03 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.06 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox