INT184451

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.51
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts2) extracellular region (Adamts2) proteinaceous extracellular matrix (Adamts2)
Anatomy Link Frequency
tendon 2
cartilage 2
Adamts2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 12 98.24 Very High Very High Very High
Osteoarthritis 55 97.64 Very High Very High Very High
cytokine 70 96.60 Very High Very High Very High
metalloproteinase 55 55.24 Quite High
Glutamate 5 43.04 Quite Low
Arthritis 40 14.96 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 55 97.64 Very High Very High Very High
Targeted Disruption 49 88.16 High High
Congenital Anomalies 20 83.12 Quite High
Cancer 10 81.68 Quite High
Necrosis 10 81.12 Quite High
Pneumonia 78 70.92 Quite High
Joint Instability 5 69.76 Quite High
Syndrome 15 62.12 Quite High
Sprains And Strains 72 61.68 Quite High
Thrombotic Thrombocytopenic Purpura 10 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most highly expressed of the ADAMTS proteinase mRNAs were those for ADAMTS-1, -5, -6, -15, -18 and -19, and observed differences between normal and late-stage OA cartilage included the lower expression of 'hyalectanase' ADAMTS proteinases (ADAMTS-1, -5, -9 and -15) and a higher expression of procollagen peptidases (ADAMTS-2 and -14).
Gene_expression (expression) of ADAMTS-2 in cartilage associated with osteoarthritis
1) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.44 Pain Relevance 0.37
It has been suggested that the relative expression patterns of ADAMTS-2 and -3 explain the relative sparing of tissues such as cartilage in dermatosparaxis [59].
Gene_expression (expression) of ADAMTS-2 in cartilage
2) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.54 Pain Relevance 0
A C-terminal extension containing a unique embedded PLAC domain is present in ADAMTS-2, -3 and -14.
Gene_expression (present) of ADAMTS-2
3) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.16 Pain Relevance 0
A lower expression level of ADAMTS-5 and higher levels of ADAMTS-2, -12, -14 and -17 were observed in chronic painful tendon.
Gene_expression (levels) of ADAMTS-2 in tendon associated with pain
4) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.39 Pain Relevance 0.38
A lower expression level of ADAMTS-5 and higher levels of ADAMTS-2, -12, -14 and -17 were observed in chronic painful tendon.
Gene_expression (expression) of ADAMTS-2 in tendon associated with pain
5) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.40 Pain Relevance 0.39
However, these peptides reside in Region C, which has several potential, N endopeptidase sites along with ?
Gene_expression (sites) of N endopeptidase
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.19 Pain Relevance 0.12
In particular, peptide 40 has a highly conserved N endopeptidase site (i.e., NxN) that lies in the middle of a pronounced ?
Gene_expression (site) of N endopeptidase
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.40 Pain Relevance 0.15

General Comments

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