INT184452

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts4) extracellular space (Adamts4) extracellular region (Adamts4)
proteinaceous extracellular matrix (Adamts4)
Anatomy Link Frequency
cartilage 2
Adamts4 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 24 98.96 Very High Very High Very High
Osteoarthritis 33 95.04 Very High Very High Very High
Glutamate 3 56.52 Quite High
Inflammation 12 55.12 Quite High
metalloproteinase 33 19.24 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 33 98.96 Very High Very High Very High
Osteoarthritis 33 95.04 Very High Very High Very High
Targeted Disruption 27 86.72 High High
Necrosis 6 37.44 Quite Low
Cancer 6 37.08 Quite Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Syndrome 9 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Thrombotic Thrombocytopenic Purpura 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potential importance of aggrecanase-mediated degradation of aggrecan in cartilage, particularly with regard to the development of arthritis, is highlighted by the report that aggrecan protects collagen fibrils from degradation by collagenases [32].
Protein_catabolism (degradation) of aggrecanase in cartilage associated with arthritis
1) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.20 Pain Relevance 0.08
Investigations into the relative contributions of ADAMTS-4 and -5 to the aggrecanase-mediated degradation of cartilage aggrecan in arthritis models have recently been conducted in mice with the use of catalytic domain knockouts of each gene [34-36].
Protein_catabolism (degradation) of aggrecanase in cartilage associated with arthritis
2) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.87 Pain Relevance 0.30
The same study also demonstrated that purified proADAMTS-4 could be cleaved by recombinant furin in cell-free experiments.
Protein_catabolism (cleaved) of proADAMTS-4
3) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0 Pain Relevance 0

General Comments

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