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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Osm) extracellular region (Osm)
Anatomy Link Frequency
mononuclear cells 1
Osm (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 100.00 Very High Very High Very High
Inflammation 5 98.78 Very High Very High Very High
Glutamate 8 93.92 High High
Nerve growth factor 1 62.92 Quite High
cINOD 1 51.12 Quite High
nMDA receptor 3 44.32 Quite Low
Potency 3 27.20 Quite Low
antidepressant 5 12.08 Low Low
metalloproteinase 11 5.00 Very Low Very Low Very Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 98.78 Very High Very High Very High
Disease 169 97.76 Very High Very High Very High
Congenital Anomalies 7 89.20 High High
Alzheimer's Dementia 15 81.96 Quite High
Necrosis 2 70.92 Quite High
Cancer 3 70.56 Quite High
Neurodegenerative Disease 2 67.60 Quite High
Targeted Disruption 13 61.04 Quite High
Apoptosis 2 58.96 Quite High
Adenocarcinoma 1 58.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of OSM by RNA interference demonstrated that MAP3K3 and OSM were required for p38 MAPK activation in response to sorbitol-induced hypertonicity [26].
Positive_regulation (required) of OSM
1) Confidence 0.24 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.14 Pain Relevance 0.05
AChEIs also influence pro-inflammatory cytokines released from peripheral blood mononuclear cells, increasing oncostatin M, IL-1?
Positive_regulation (increasing) of oncostatin M in mononuclear cells associated with inflammation and cytokine
2) Confidence 0.07 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.71 Pain Relevance 0.28
together with oncostatin M, but not either cytokine alone, upregulated ADAMTS-4 mRNA, whereas ADAMTS-5 mRNA was upregulated by IL-1?
Positive_regulation (upregulated) of oncostatin M associated with cytokine
3) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.56 Pain Relevance 0.21

General Comments

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