INT184466

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts1, Adamts4) extracellular region (Adamts1, Adamts4) proteinaceous extracellular matrix (Adamts1, Adamts4)
extracellular space (Adamts4)
Adamts1 (Mus musculus)
Adamts4 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 8 86.80 High High
Inflammation 4 86.40 High High
Osteoarthritis 11 80.64 Quite High
metalloproteinase 11 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 96.36 Very High Very High Very High
Arthritis 11 86.80 High High
Osteoarthritis 11 80.64 Quite High
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Thrombotic Thrombocytopenic Purpura 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together these studies suggest that, at least in these mouse models, ADAMTS-5 is primarily responsible for the increased aggrecanase activity.
ADAMTS Positive_regulation (responsible) of aggrecanase
1) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 1.03 Pain Relevance 0.30

General Comments

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