INT184473

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.73
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
HPAC 2
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 12 76.12 Quite High
cINOD 13 58.88 Quite High
Central nervous system 1 45.84 Quite Low
addiction 2 45.44 Quite Low
COX-2 inhibitor 10 25.84 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
neuralgia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 210 97.32 Very High Very High Very High
Klatskin's Tumor 28 96.80 Very High Very High Very High
Ovarian Cancer 1 95.60 Very High Very High Very High
Pancreatic Cancer 23 93.92 High High
Apoptosis 101 87.68 High High
Biliary Cancer 20 84.16 Quite High
Bile Duct Neoplasms 11 76.60 Quite High
Stomach Cancer 1 71.52 Quite High
Skin Cancer 5 64.24 Quite High
Cholangiocarcinoma 3 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also noted the re-expression of cyclin D1, which was down-regulated in the stable 199bSC1 clone.
Regulation (regulated) of Gene_expression (-) of cyclin D1
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.25 Pain Relevance 0
In our study, there was no difference in p53 and cyclin D1 overexpression based on anatomic site, and also they were no prognostic impact on survival in BDC and GB cancer, respectively.
Neg (no) Regulation (difference) of Gene_expression (overexpression) of cyclin D1 associated with klatskin's tumor and cancer
2) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.48 Pain Relevance 0.04
We observed no change in expression of the canonical Wnt target genes Cyclin D1 or C-myc by either RNA assay (data not shown).
Neg (no) Regulation (change) of Gene_expression (expression) of Cyclin D1
3) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
It is not clear from our studies that celecoxib directly affects cell cycle distribution by regulating cyclin D1 levels, which is one of the major cyclins known to be upregulated during cancer.
Regulation (regulating) of Gene_expression (levels) of cyclin D1 associated with cancer
4) Confidence 0.10 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.80 Pain Relevance 0.06
However, it is unclear why there was no change of Cyclin D1 level in spite of G1 phase arrest and overexpression of p21cip1 in HPAC cells.
Neg (no) Regulation (change) of Gene_expression (overexpression) of Cyclin D1 in HPAC
5) Confidence 0.04 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.20 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox