INT184478

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.72
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
macrophages 3
MDA-MB-468 3
neutrophils 1
MDA-MB-231 1
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 28 58.48 Quite High
Inflammation 20 44.20 Quite Low
Inflammatory response 18 21.84 Low Low
dexamethasone 4 12.40 Low Low
cINOD 26 5.00 Very Low Very Low Very Low
COX-2 inhibitor 20 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 124 98.44 Very High Very High Very High
Breast Cancer 84 93.12 High High
Meningitis 74 92.64 High High
Apoptosis 140 87.24 High High
Adhesions 2 64.44 Quite High
INFLAMMATION 46 59.84 Quite High
Bacterial Meningitis 6 40.00 Quite Low
Injury 10 35.28 Quite Low
Cancer 122 13.52 Low Low
Hearing Impairment 4 9.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EP2 and EP4 are reported to couple exclusively with G?
Negative_regulation (reported) of EP2 Binding (couple) of
1) Confidence 0.41 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
IL-10 administration suppressed the formation of PGE-2 by neutrophils and macrophages, in which case the expression of TLR2 in these cells suppressed and induced the expression of CR3.
Negative_regulation (suppressed) of PGE-2 Binding (formation) of in macrophages
2) Confidence 0.03 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.63 Pain Relevance 0.03
To determine whether celecoxib-induced growth inhibition could be reversed by exogenous PGE2, PGE2 was added to cultures of MDA-MB-231 and MDA-MB-468 cells treated with constant dose (40 ?
Negative_regulation (reversed) of PGE2 Binding (exogenous) of in MDA-MB-468
3) Confidence 0.03 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.23 Pain Relevance 0
IL-10 administration suppressed the formation of PGE-2 by neutrophils and macrophages, in which case the expression of TLR2 in these cells suppressed and induced the expression of CR3.
Negative_regulation (suppressed) of PGE-2 in neutrophils Binding (formation) of in macrophages
4) Confidence 0.01 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.63 Pain Relevance 0.03
To determine whether celecoxib-induced growth inhibition could be reversed by exogenous PGE2, PGE2 was added to cultures of MDA-MB-231 and MDA-MB-468 cells treated with constant dose (40 ?
Negative_regulation (reversed) of PGE2 in MDA-MB-231 Binding (exogenous) of in MDA-MB-468
5) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.23 Pain Relevance 0

General Comments

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