INT184482

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.70
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
SH-SY5Y 2
facet 2
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 8 89.60 High High
COX-2 inhibitor 10 77.52 Quite High
GABAergic 1 67.24 Quite High
cINOD 15 64.32 Quite High
monoamine 1 54.12 Quite High
Dopamine 13 52.28 Quite High
Glutamate 4 28.72 Quite Low
Substantia nigra 19 7.88 Low Low
Inflammation 36 5.00 Very Low Very Low Very Low
Inflammatory response 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 196 100.00 Very High Very High Very High
Death 97 98.08 Very High Very High Very High
Parkinson's Disease 83 97.92 Very High Very High Very High
Neuroblastoma 1 97.68 Very High Very High Very High
Disease 147 91.68 High High
Stress 7 90.96 High High
Breast Cancer 42 86.16 High High
Sprains And Strains 75 80.16 Quite High
Cancer 65 75.44 Quite High
Necrosis 9 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of GFP-BAX were unable to stimulate higher levels of cell death.
Positive_regulation (levels) of Positive_regulation (Increased) of GFP-BAX associated with death
1) Confidence 0.41 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2964639 Disease Relevance 0.74 Pain Relevance 0
This facet of the apoptotic activation cascade does not necessarily result in BAX activation, however, and similarly the concentration of BAX likely does not impact the stoichiometric balance between them.
Neg (not) Positive_regulation (result) of Positive_regulation (activation) of BAX in facet associated with apoptosis
2) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.80 Pain Relevance 0.09
For the release of cytochrome C into the cytosol, an activation of Bax to permeabilize the outer mitochondrial membrane appears to be necessary [60].

2.4.1.4c.iv.

Positive_regulation (necessary) of Positive_regulation (activation) of Bax
3) Confidence 0.17 Published 2010 Journal Neurology Research International Section Body Doc Link PMC2989867 Disease Relevance 0.66 Pain Relevance 0.09
At the molecular level, pAkt was inactivated with increased activation of proapoptotic protein Bax and caspases 3 and 7.
Positive_regulation (increased) of Positive_regulation (activation) of Bax
4) Confidence 0.16 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.95 Pain Relevance 0.15
In agreement, in SH-SY5Y neuroblastoma cells, MPTP and MPP+ increase the mitochondrial production of NO, suggesting an activating effect on mtNOS that is associated to Bax increase, release of cytochrome c and caspase activation (Dennis and Bennett, 2003).
Positive_regulation (associated) of Positive_regulation (increase) of Bax in SH-SY5Y associated with parkinson's disease and neuroblastoma
5) Confidence 0.11 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2947925 Disease Relevance 0.81 Pain Relevance 0
We hypothesized that the PB1-F2 C-terminal domain may promote mitochondrial outer membrane permeabilization (MOMP) via the activation of the pro-apoptotic Bcl-2 family effector proteins BAX and BAK.
Spec (may) Positive_regulation (promote) of Positive_regulation (activation) of BAX associated with apoptosis
6) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.74 Pain Relevance 0

General Comments

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