INT18451

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
cortex 2
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 11 100.00 Very High Very High Very High
Kinase C 2 98.84 Very High Very High Very High
antidepressant 11 98.36 Very High Very High Very High
adenocard 1 94.00 High High
ischemia 42 84.40 Quite High
addiction 46 82.80 Quite High
alcohol 275 82.36 Quite High
Kinase C inhibitor 1 80.24 Quite High
opiate 1 66.08 Quite High
Anterior cingulate 1 42.00 Quite Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 366 99.54 Very High Very High Very High
Anxiety Disorder 13 98.96 Very High Very High Very High
Alcohol Addiction 105 97.28 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 8 94.40 High High
Affective Disorder 9 86.00 High High
Cv Unclassified Under Development 42 84.40 Quite High
Congenital Anomalies 2 61.44 Quite High
Injury 22 56.44 Quite High
Depression 55 38.16 Quite Low
Aggression 12 27.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In nonalcoholic suicides, there is a localized increase in 5-HT1A binding in ventral prefrontal cortex, hypothesized to be a response to less serotonin input which had been hypothesized to be related to increased impulsivity and emotional dysregulation [161].
Positive_regulation (increase) of 5-HT1A Binding (binding) of in cortex associated with suicidal behaviour, attention deficit hyperactivity disorder and serotonin
1) Confidence 0.67 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872355 Disease Relevance 1.30 Pain Relevance 0.28
Their singular affinity for the serotonin (5-hydroxytryptamine [5-HT]) type 1A (5-HT1A) receptor subtype may be the factor responsible for the therapeutic activity of these agents.
Positive_regulation (responsible) of 5-HT1A Binding (affinity) of associated with serotonin
2) Confidence 0.49 Published 1990 Journal J Clin Psychopharmacol Section Abstract Doc Link 1973936 Disease Relevance 0.31 Pain Relevance 0.20
Cellular stressors activate protein kinase via G-protein-coupled receptor binding and membrane phospholipase activation.
Positive_regulation (activate) of G-protein-coupled receptor Binding (binding) of
3) Confidence 0.03 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2231361 Disease Relevance 0.35 Pain Relevance 0.33

General Comments

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