INT184511

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.86
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cells 2
MDA-MB-468 2
urine 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 10 88.00 High High
pain flank 1 46.52 Quite Low
Dysuria 1 35.12 Quite Low
Inflammation 15 32.96 Quite Low
cytokine 42 5.00 Very Low Very Low Very Low
imagery 27 5.00 Very Low Very Low Very Low
Central nervous system 23 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
cINOD 13 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 476 98.78 Very High Very High Very High
Breast Cancer 68 94.48 High High
Cold Sores 367 94.08 High High
Colon Cancer 7 86.72 High High
Metastasis 70 68.40 Quite High
Transitional Cell Carcinoma 19 68.00 Quite High
Skin Cancer 47 66.84 Quite High
Targeted Disruption 5 65.12 Quite High
Advanced Or Metastatic Breast Cancer 16 57.08 Quite High
Nicotine Addiction 3 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In T1 group, VEGF level reduced in serum, but increased in urine after BCG therapy.
Positive_regulation (increased) of Negative_regulation (reduced) of VEGF in urine
1) Confidence 0.46 Published 2010 Journal Urology Annals Section Body Doc Link PMC2955232 Disease Relevance 0.53 Pain Relevance 0
Although increases in serum total VEGF concentration were seen, this was likely a result of an increase in VEGF synthesis/distribution, a decrease in VEGF clearance caused by complex formation between VEGF and bevacizumab, or both.
Positive_regulation (increase) of Negative_regulation (decrease) of VEGF
2) Confidence 0.24 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721345 Disease Relevance 0.18 Pain Relevance 0
Our data suggest that treatment with celecoxib caused a dose-dependent downregulation of VEGF in the MDA-MB-231 cells but not in the MDA-MB-468 cells (Fig. 6b).
Neg (not) Positive_regulation (caused) of Negative_regulation (downregulation) of VEGF in MDA-MB-468
3) Confidence 0.20 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.42 Pain Relevance 0.09
To further validate whether the increased activation of JNK-mediated downregulation of VEGF-C is dependent on podoplanin, the levels of phosphorylated JNK and VEGF-C mRNA were examined using siRNA methods.
Spec (whether) Positive_regulation (activation) of Spec (whether) Negative_regulation (downregulation) of VEGF
4) Confidence 0.10 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.05 Pain Relevance 0
Podoplanin-induced VEGF-C downregulation is mediated by an increase in the level of activated JNK in LSCCs
Positive_regulation (mediated) of Negative_regulation (downregulation) of VEGF
5) Confidence 0.09 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.39 Pain Relevance 0
It was observed that in tumour and prolipherating endothelial cells, combination treatment enhanced cyclin D1 and VEGF inhibition.
Positive_regulation (enhanced) of Negative_regulation (inhibition) of VEGF in endothelial cells associated with cancer
6) Confidence 0.08 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.30 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox