INT184541

Context Info Confidence 0.10 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.37 Pain Relevance 0.09

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2) plasma membrane (Gpbar1) cytoskeleton organization (Ccl2) signal transducer activity (Gpbar1)

Anatomy Link Frequency macrophage 1 Ccl2 (Rattus norvegicus) Gpbar1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 13 98.86 chemokine 7 73.12 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Renal Disease 1 99.90 Diabetes Mellitus 58 99.62 Hypertension 52 99.36 INFLAMMATION 13 98.86 Adhesions 3 96.58 Disease 6 77.24 Polyuria 1 45.72 Body Weight 5 41.36 Hypertrophy 1 32.32 Albuminuria 1 29.08

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Expression of mediators regulating macrophage infiltration (MCP-1, osteopontin, RANTES) and adhesion molecules involved in macrophage infiltration (ICAM-1, VCAM-1) was investigated to further elucidate inflammatory pathways in hypertensive and diabetic renal disease: In TGR rats, renal MCP-1 and osteopontin mRNA steady state levels were increased compared to SD controls, as determined by real-time RT-PCR (figure 3A and 3B).

MCP-1 Positive_regulation (rats) of TGR in macrophage associated with inflammation, diabetes mellitus, renal disease, hypertension and adhesions

1) Confidence 0.10 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.37 Pain Relevance 0.09

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