INT184547

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.44
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Spp1) extracellular space (Spp1) extracellular region (Spp1)
cell adhesion (Spp1) cytoplasm (Spp1)
Anatomy Link Frequency
podocytes 1
Spp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 50 99.84 Very High Very High Very High
chemokine 13 98.80 Very High Very High Very High
Inflammation 70 89.20 High High
monoamine 27 86.84 High High
adenocard 21 67.68 Quite High
depression 39 56.80 Quite High
fluoxetine 33 50.28 Quite High
antidepressant 138 50.00 Quite Low
Hippocampus 27 50.00 Quite Low
sSRI 15 44.40 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 58 99.32 Very High Very High Very High
Hypertension 52 95.68 Very High Very High Very High
Cancer 54 89.44 High High
INFLAMMATION 72 89.20 High High
Obesity 3 89.12 High High
Metastasis 3 86.96 High High
Injury 10 85.24 High High
Apoptosis 64 83.84 Quite High
Overdose 2 81.28 Quite High
Myocardial Infarction 27 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2, GDF15 (growth differentiation factor 15), and LepR (leptin receptor), which were over expressed, and SPP1 (secreted phosphoprotein 1), which was down-regulated.
Localization (secreted) of SPP1
1) Confidence 0.58 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 0.66 Pain Relevance 0.26
2, GDF15 (growth differentiation factor 15), and LepR (leptin receptor), which were over expressed, and SPP1 (secreted phosphoprotein 1), which was down-regulated.
Localization (secreted) of phosphoprotein 1
2) Confidence 0.57 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 0.66 Pain Relevance 0.26
Secreted phosphoprotein 1 (SSP1) is an extracellular structural protein and an organic component of bone.
Localization (Secreted) of phosphoprotein 1
3) Confidence 0.57 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.06 Pain Relevance 0.09
Interestingly, glomerular MCP-1 was localized in podocytes, similar to the localization of osteopontin in glomeruli of diabetic TGR described by Kelly et al. [13].
Localization (localization) of osteopontin in podocytes associated with diabetes mellitus
4) Confidence 0.44 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.33 Pain Relevance 0.12
Measurements of MCP-1, IL-6, and osteopontin (OPN) protein concentrations were performed using the Searchlight™ multiplex sample testing by Endogen, PerbioScience (Brebieres, France).


Localization (Measurements) of osteopontin
5) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.14 Pain Relevance 0.10
Similarly stimulation of eEPC with EPO resulted in a 2.8 fold increase of secreted phosphoprotein 1, a cytokine involved in angiogenesis (Fig. 1C).


Localization (secreted) of phosphoprotein 1 associated with cytokine
6) Confidence 0.01 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954875 Disease Relevance 0.60 Pain Relevance 0.18

General Comments

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