INT184549

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 10.35
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpbar1) signal transducer activity (Gpbar1)
Anatomy Link Frequency
Kidney 2
Urine 1
Gpbar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 63 97.60 Very High Very High Very High
Inflammation 117 85.96 High High
anesthesia 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 522 100.00 Very High Very High Very High
Hypertension 468 100.00 Very High Very High Very High
Body Weight 45 99.50 Very High Very High Very High
Hypertrophy 9 97.92 Very High Very High Very High
Adhesions 27 95.68 Very High Very High Very High
Albuminuria 9 94.68 High High
Polyuria 9 94.56 High High
Disease 54 93.24 High High
Renal Disease 9 88.04 High High
Sclerosis 9 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kidney weight/body weight ratio was significantly increased in SD-STZ, TGR and TGR-STZ versus SD controls as well as in TGR-STZ versus TGR (table 1).
Positive_regulation (increased) of TGR in Kidney associated with body weight
1) Confidence 0.13 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.72 Pain Relevance 0
Kidney weight/body weight ratio was significantly increased in SD-STZ, TGR and TGR-STZ versus SD controls as well as in TGR-STZ versus TGR (table 1).
Positive_regulation (increased) of TGR in Kidney associated with body weight
2) Confidence 0.13 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.73 Pain Relevance 0
Urine production was slightly higher in TGR than in SD, but significantly elevated in the diabetic groups SD-STZ and TGR-STZ (table 1).
Positive_regulation (elevated) of TGR in Urine associated with diabetes mellitus
3) Confidence 0.13 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.98 Pain Relevance 0
STZ-induced diabetes mellitus of five weeks did not significantly increase MCP-1 and osteopontin mRNA in SD rats and did not augment the upregulation of MCP-1 mRNA in TGR (figure 3).
Positive_regulation (upregulation) of TGR associated with diabetes mellitus
4) Confidence 0.10 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.11 Pain Relevance 0.09
Real-time RT-PCR was used to screen for large differences of the expression of several proinflammatory molecules, and we focused on the factors which exhibited a clear induction in diabetic, hypertensive TGR.
Spec (clear) Positive_regulation (induction) of TGR associated with diabetes mellitus and hypertension
5) Confidence 0.09 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.24 Pain Relevance 0.03
We induced STZ diabetes in adult male TGR whereas Kelly et al. employed adolescent (6 week old) female TGR [13].
Positive_regulation (induced) of TGR associated with diabetes mellitus
6) Confidence 0.09 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.41 Pain Relevance 0.07
Injection of STZ induced diabetes mellitus equally well in SD and in TGR.
Positive_regulation (induced) of TGR associated with diabetes mellitus
7) Confidence 0.09 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 0.31 Pain Relevance 0
Quantification of glomerular and interstitial MCP-1 staining demonstrated a mild increase in SD-STZ rats and a massive increase in TGR and TGR-STZ (figure 6A).
Positive_regulation (increase) of TGR
8) Confidence 0.09 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 0.43 Pain Relevance 0
Quantification of glomerular and interstitial MCP-1 staining demonstrated a mild increase in SD-STZ rats and a massive increase in TGR and TGR-STZ (figure 6A).
Positive_regulation (increase) of TGR
9) Confidence 0.09 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 0.42 Pain Relevance 0

General Comments

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