INT18455

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Context Info
Confidence 0.70
First Reported 1984
Last Reported 2003
Negated 1
Speculated 1
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 1.55
Pain Relevance 7.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
dorsal root ganglia 4
plasma 2
hippocampal formation 2
motoneurons 2
interneurons 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 112 100.00 Very High Very High Very High
Cholecystokinin 25 100.00 Very High Very High Very High
Neuropeptide 13 100.00 Very High Very High Very High
antagonist 5 99.56 Very High Very High Very High
Enkephalin 7 99.24 Very High Very High Very High
Calcitonin gene-related peptide 3 99.24 Very High Very High Very High
IPN 2 98.60 Very High Very High Very High
substance P 6 95.80 Very High Very High Very High
Hippocampus 6 95.68 Very High Very High Very High
qutenza 6 92.12 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 98.60 Very High Very High Very High
Injury 8 98.08 Very High Very High Very High
Arthritis 1 86.12 High High
Nociception 3 85.60 High High
Neurogenic Inflammation 1 84.96 Quite High
Natriuresis 4 75.00 Quite High
INFLAMMATION 4 75.00 Quite High
Hyperalgesia 1 73.20 Quite High
Generalized Anxiety Disorder 1 50.40 Quite High
Fistula 1 42.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether biosynthesis of somatostatin is enhanced in the primary sensory neurons by inflammatory pain, we examined the effects of adjuvant inoculation on the content of immunoreactive somatostatin, mainly composed of somatostatin-14 and somatostatin-28, in the dorsal root ganglia and the spinal cord of the rat.
Spec (whether) Positive_regulation (enhanced) of Gene_expression (biosynthesis) of somatostatin in dorsal root ganglia associated with ipn, somatostatin and spinal cord
1) Confidence 0.70 Published 1990 Journal Neurosci. Res. Section Abstract Doc Link 1977111 Disease Relevance 0.25 Pain Relevance 0.58
Potassium-induced depolarization stimulates somatostatin gene expression in cultured fetal rat cerebrocortical cells.
Positive_regulation (stimulates) of Gene_expression (expression) of somatostatin associated with somatostatin
2) Confidence 0.63 Published 1993 Journal J Pediatr Endocrinol Section Title Doc Link 7920985 Disease Relevance 0 Pain Relevance 0.30
Stimulation with 100 mM KCl increased the recovered somatostatin by 138% (P < 0.05).
Positive_regulation (increased) of Gene_expression (recovered) of somatostatin associated with somatostatin
3) Confidence 0.50 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.42
Stimulation with 100 mM KCl increased the recovered somatostatin by 138% (P < 0.05).
Positive_regulation (recovered) of Gene_expression (recovered) of somatostatin associated with somatostatin
4) Confidence 0.50 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.42
These findings indicate a major distinction between those peptides (vasoactive intestinal polypeptide, cholecystokinin-octapeptide, somatostatin, neurotensin) which are found in cell bodies intrinsic to the hippocampal formation and those peptides (substance P, methionine-enkephalin) which are found only in hippocampal afferents.
Positive_regulation (distinction) of Gene_expression (peptides) of somatostatin in hippocampal formation associated with somatostatin, enkephalin, cholecystokinin and substance p
5) Confidence 0.49 Published 1984 Journal Neuroscience Section Abstract Doc Link 6200800 Disease Relevance 0 Pain Relevance 0.77
Neutralization of ambient somatostatin with somatostatin antibody (final dilution 1:200) increased basal ANP secretion by 70+/-8% (P<001), implying that endogenous somatostatin inhibits ANP secretion.
Positive_regulation (Neutralization) of Gene_expression (Neutralization) of somatostatin associated with somatostatin
6) Confidence 0.48 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.14 Pain Relevance 0.78
Neutralization of ambient somatostatin with somatostatin antibody (final dilution 1:200) increased basal ANP secretion by 70+/-8% (P<001), implying that endogenous somatostatin inhibits ANP secretion.
Positive_regulation (Neutralization) of Gene_expression (Neutralization) of somatostatin associated with somatostatin
7) Confidence 0.48 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.14 Pain Relevance 0.77
A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Bötzinger complex.
Positive_regulation (levels) of Gene_expression (expressing) of somatostatin in interneurons associated with somatostatin and enkephalin
8) Confidence 0.48 Published 2003 Journal J. Comp. Neurol. Section Title Doc Link 12508323 Disease Relevance 0.05 Pain Relevance 0.67
These results indicate that one mechanism by which urethane induced low basal gastric acid secretion involved increased synthesis and release of endogenous somatostatin and associated inhibition of gastrin secretion.
Positive_regulation (increased) of Gene_expression (synthesis) of somatostatin associated with somatostatin
9) Confidence 0.46 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0 Pain Relevance 0.37
After intraperitoneal instillation of acid there was an increase in the plasma levels of somatostatin and a decrease of calcitonin gene-related peptide, but there was no change of neuropeptide Y, vasoactive intestinal peptide, substance P, neurokinin A, or neurotensin.
Positive_regulation (increase) of Gene_expression (levels) of somatostatin in plasma associated with neuropeptide, somatostatin, substance p and calcitonin gene-related peptide
10) Confidence 0.45 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530148 Disease Relevance 0.07 Pain Relevance 0.23
In contrast, the axotomy-induced heterogenous increases in somatostatin and neuropeptide tyrosine mRNA expression in ipsilateral motoneurons remained elevated, or, in the case of somatostatin, continued to increase for the time period studied (1 month).
Positive_regulation (increases) of Gene_expression (expression) of somatostatin in motoneurons associated with neuropeptide and somatostatin
11) Confidence 0.43 Published 1993 Journal Exp Brain Res Section Abstract Doc Link 7686109 Disease Relevance 0.16 Pain Relevance 0.38
Immunoneutralization of endogenous somatostatin with somatostatin monoclonal antibody (2 mg ip) did not reverse the protective actions of CCK.
Positive_regulation (Immunoneutralization) of Gene_expression (Immunoneutralization) of somatostatin associated with somatostatin and cholecystokinin
12) Confidence 0.38 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8897890 Disease Relevance 0.21 Pain Relevance 0.79
Immunoneutralization of endogenous somatostatin with somatostatin monoclonal antibody (2 mg ip) did not reverse the protective actions of CCK.
Positive_regulation (Immunoneutralization) of Gene_expression (Immunoneutralization) of somatostatin associated with somatostatin and cholecystokinin
13) Confidence 0.38 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8897890 Disease Relevance 0.21 Pain Relevance 0.79
Adjuvant injection increased preprotachykinin (PPT) and calcitonin gene-related peptide (CGRP) messenger RNA (mRNA) after 8 h, whereas somatostatin mRNA expression remained unchanged, in innervating L5 DRG neurons.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of somatostatin mRNA in DRG associated with somatostatin and calcitonin gene-related peptide
14) Confidence 0.09 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7970189 Disease Relevance 0.33 Pain Relevance 0.57

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