INT184558

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Aurka) cytoskeleton (Aurka) nucleus (Aurka)
cell cycle (Aurka) cell division (Aurka) cytoplasm (Aurka)
Anatomy Link Frequency
hepatocytes 3
Aurka (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 12 5.00 Very Low Very Low Very Low
isoflurane 12 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 94.68 High High
Chronic Renal Failure 30 94.24 High High
Targeted Disruption 48 82.80 Quite High
Myocardial Infarction 7 78.80 Quite High
Left Ventricular Hypertrophy 2 74.88 Quite High
Stress 5 71.12 Quite High
Renal Insufficiency 2 61.04 Quite High
Cardiovascular Disease 5 57.72 Quite High
Disorder Of Lipid Metabolism 23 10.96 Low Low
Death 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.
Gene_expression (levels) of Aurora A
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.13 Pain Relevance 0
Continuous EGF stimulation for 72 hr was able to increase Erk1/2 phosphorylation and restore both DNA synthesis and protein levels of cdc2, Aurora A, Aurora B, and Mad1and 2 albeit to a considerably lesser degree as compared to control hepatocytes, again underscoring a key contribution of c-Met to maintaining an adequate levels of cell proliferation.


Gene_expression (levels) of Aurora A in hepatocytes
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
Continuous EGF stimulation for 72 hr was able to increase Erk1/2 phosphorylation and restore both DNA synthesis and protein levels of cdc2, Aurora A, Aurora B, and Mad1and 2 albeit to a considerably lesser degree as compared to control hepatocytes, again underscoring a key contribution of c-Met to maintaining an adequate levels of cell proliferation.


Gene_expression (synthesis) of Aurora A in hepatocytes
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
A persistent EGF supplementation in vitro was able only partially rescue the effect of Erk1/2 downregulation in c-Met depleted hepatocytes and restore to some extent the levels of cdc2, Aurora A and B, and Mad2.
Gene_expression (levels) of Aurora A in hepatocytes
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
Furthermore, it is hoped that AURORA will produce data on the cost effectiveness (cost due to hospitalisation and cost per year of life saved) and long-term safety of rosuvastatin treatment in ESRD patients receiving chronic haemodialysis.
Gene_expression (produce) of AURORA associated with chronic renal failure
5) Confidence 0.09 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1175096 Disease Relevance 1.00 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox