INT18457

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1988
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 4.28
Pain Relevance 18.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
neurons 7
nucleus 2
spinal 2
pituitary 2
plasma 1
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 165 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Calcitonin gene-related peptide 13 99.96 Very High Very High Very High
substance P 11 99.96 Very High Very High Very High
electroacupuncture 24 99.92 Very High Very High Very High
neuralgia 2 99.34 Very High Very High Very High
Neuropeptide 22 99.32 Very High Very High Very High
Enkephalin 15 99.32 Very High Very High Very High
Central grey 8 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 99.24 Very High Very High Very High
Arthritis 10 99.12 Very High Very High Very High
Ganglion Cysts 12 98.24 Very High Very High Very High
Fistula 1 98.12 Very High Very High Very High
Neuropathic Pain 14 96.80 Very High Very High Very High
Generalized Anxiety Disorder 1 96.32 Very High Very High Very High
Convulsion 6 96.24 Very High Very High Very High
Sciatic Neuropathy 2 95.16 Very High Very High Very High
Pain 3 94.16 High High
Body Weight 1 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the methods of in situ hybridization (ISHH), ISHH combined with immunocytochemistry ABC and image processing, somatostatin (SOM) mRNA level and coexistence of SOM mRNA and 5-HT in the nucleus raphe dorsalis (RD) of rat were studied in the normal group, noxious stimulation group, simple electroacupuncture group and electroacupuncture analgesia group (EA).
Transcription (level) of somatostatin in nucleus associated with somatostatin, electroacupuncture, raphe and analgesia
1) Confidence 0.69 Published 1996 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 9387336 Disease Relevance 0 Pain Relevance 0.66
Relative to the distribution of serotonin, somatostatin, peptide histidine isoleucine (PHI), methionine enkephalin, substance P and neurotensin-containing neuronal perikarya in the PAG, neurons containing immunoreactive pYT 22 occupied a unique location in the ventrolateral PAG.
Transcription (distribution) of somatostatin in neurons associated with somatostatin, enkephalin, central grey, serotonin and substance p
2) Confidence 0.67 Published 1988 Journal Brain Res. Section Abstract Doc Link 3147123 Disease Relevance 0.64 Pain Relevance 0.65
Most SST-ir neurons (>90%) contained vesicular glutamate transporter 2 (VGLUT2) mRNA, and terminals immunoreactive for SST and VGLUT2 protein were found in their midst.
Transcription (found) of SST in neurons associated with glutamate and somatostatin
3) Confidence 0.66 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12508323 Disease Relevance 0.10 Pain Relevance 0.73
Fifteen minutes after injection of urethane, somatostatin messenger RNA concentrations were increased by 128% compared with those in nontreated rats.
Transcription (concentrations) of somatostatin associated with somatostatin
4) Confidence 0.52 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0.10 Pain Relevance 0.50
Treatments were performed in defined insulin-free medium between days 6 and 8 of culture, since the maximal effects of NTs on somatostatin content and mRNA expression were observed after 48-h incubations.
Transcription (expression) of somatostatin associated with somatostatin
5) Confidence 0.48 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.64
To understand their functional significance and sites of action on hypothalamic neurons, we examined the effects of their cognate ligands on neuropeptide content and messenger RNA (mRNA) expression in somatostatin neurons present in fetal rat hypothalamic cultures.
Transcription (expression) of somatostatin in neurons associated with somatostatin and neuropeptide
6) Confidence 0.46 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.42
Effects of electroacupuncture on expression of somatostatin and preprosomatostatin mRNA in dorsal root ganglions and spinal dorsal horn in neuropathic pain rats.
Transcription (expression) of somatostatin in dorsal root ganglions associated with ganglion cysts, neuralgia, spinal dorsal horn, neuropathic pain, somatostatin and electroacupuncture
7) Confidence 0.41 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15970377 Disease Relevance 0.78 Pain Relevance 1.66
In control rats, somatostatin-1 to somatostatin-4 receptor messenger RNAs were found in the pyramidal layer and granule cell layer of the dentate gyrus.
Transcription (found) of somatostatin in granule cell associated with somatostatin
8) Confidence 0.40 Published 1995 Journal Neuroscience Section Abstract Doc Link 7617164 Disease Relevance 0.10 Pain Relevance 0.68
The same treatment increased somatostatin mRNA and immunostaining intensity of somatostatin neurons, but had no effect on the number of these labeled neurons.
Transcription (intensity) of somatostatin in neurons associated with somatostatin
9) Confidence 0.36 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.75
The same treatment increased somatostatin mRNA and immunostaining intensity of somatostatin neurons, but had no effect on the number of these labeled neurons.
Transcription (intensity) of somatostatin in neurons associated with somatostatin
10) Confidence 0.36 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.75
The cisplatin treatment significantly increased plasma somatostatin immunoreactivity and the expression of SSTR4 receptor detected both on the 11th and 22nd post-treatment days with no change in either CGRP, NK1, and NK2 receptor gene expression or plasma CGRP and substance P levels.
Transcription (immunoreactivity) of somatostatin in plasma associated with somatostatin, substance p and calcitonin gene-related peptide
11) Confidence 0.35 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.20 Pain Relevance 0.70
Immunoreactive galanin, calcitonin gene-related peptide, substance P and somatostatin and their mRNAs were found in cell bodies in dorsal root ganglia of untreated monkeys and on the contralateral side of the monkeys with unilateral sciatic nerve lesion.
Transcription (found) of somatostatin in sciatic nerve associated with somatostatin, sciatic nerve, substance p and calcitonin gene-related peptide
12) Confidence 0.34 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 7686215 Disease Relevance 0.10 Pain Relevance 0.67
Antral gastrin contents, somatostatin contents, gastrin mRNA expression, and somatostatin mRNA expression were not significantly affected by capsaicin pretreatment.
Transcription (expression) of somatostatin associated with qutenza and somatostatin
13) Confidence 0.30 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.72
Antral gastrin contents, somatostatin contents, gastrin mRNA expression, and somatostatin mRNA expression were not significantly affected by capsaicin pretreatment.
Transcription (expression) of somatostatin associated with qutenza and somatostatin
14) Confidence 0.30 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.72
Antral gastrin contents, somatostatin contents, gastrin mRNA expression, and somatostatin mRNA expression were not significantly affected by capsaicin pretreatment.
Transcription (expression) of somatostatin associated with qutenza and somatostatin
15) Confidence 0.30 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.71
In contrast, cholecystokinin, vasoactive intestinal peptide, substance P, somatostatin, dynorphin-B and neurotensin, although present in some medial septal neurons, were never observed in neurons projecting to the hippocampus.
Transcription (observed) of somatostatin in medial associated with dynorphin, somatostatin, hippocampus, cholecystokinin and substance p
16) Confidence 0.28 Published 1988 Journal Peptides Section Abstract Doc Link 2470066 Disease Relevance 0 Pain Relevance 0.55
In the control animals, beta-preprotachykinin, gamma-preprotachykinin, calcitonin gene-related peptide, somatostatin, trkA, trkB and trkC messenger RNAs were found in about 30%, 30%, 40%, 10%, 40%, 5% and 20% of the lumbar dorsal root ganglion neurons, respectively.
Transcription (found) of somatostatin in neurons associated with ganglion cysts, root ganglion neuron, somatostatin and calcitonin gene-related peptide
17) Confidence 0.28 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.19 Pain Relevance 0.82
In contrast to the decrease in enkephalin and substance P mRNA expression, somatostatin mRNA-expressing neurons were largely preserved.
Transcription (expressing) of somatostatin in neurons associated with somatostatin, enkephalin and substance p
18) Confidence 0.25 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7523600 Disease Relevance 0.07 Pain Relevance 0.40
The mechanisms involved in such effects were evaluated by measuring pituitary GH mRNA levels and hypothalamic levels of GH-releasing hormone (GHRH) and somatostatin (SRIF) mRNAs.
Transcription (levels) of somatostatin in pituitary associated with somatostatin
19) Confidence 0.20 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.31
Effects of electroacupuncture on expression of somatostatin and preprosomatostatin mRNA in dorsal root ganglions and spinal dorsal horn in neuropathic pain rats.
Transcription (expression) of somatostatin in spinal associated with ganglion cysts, neuralgia, spinal dorsal horn, neuropathic pain, somatostatin and electroacupuncture
20) Confidence 0.14 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15970377 Disease Relevance 0.78 Pain Relevance 1.66

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox