INT184583

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.76
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 11 100.00 Very High Very High Very High
Morphine 71 98.00 Very High Very High Very High
spinal dorsal horn 12 97.92 Very High Very High Very High
bradykinin 10 96.32 Very High Very High Very High
Sciatic nerve 11 96.00 Very High Very High Very High
opioid receptor 16 91.36 High High
Peripheral nerve injury 2 90.08 High High
Hyperalgesia 17 88.00 High High
Neuropathic pain 16 86.68 High High
Preemptive analgesia 7 79.44 Quite High
Disease Link Frequency Relevance Heat
Nociception 39 97.64 Very High Very High Very High
Injury 65 96.92 Very High Very High Very High
Nervous System Injury 24 96.28 Very High Very High Very High
Hyperalgesia 19 88.00 High High
Neuropathic Pain 22 86.68 High High
INFLAMMATION 26 70.72 Quite High
Increased Venous Pressure Under Development 11 53.52 Quite High
Pain 56 37.68 Quite Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been reported that majority of PKC?
Regulation (reported) of Phosphorylation (majority) of PKC
1) Confidence 0.21 Published 2005 Journal Mol Pain Section Body Doc Link PMC1175856 Disease Relevance 1.10 Pain Relevance 1.57
Phosphorylation by PKC has been shown to sensitize TRPV1 [32, 138].
Regulation (sensitize) of Phosphorylation (Phosphorylation) of PKC
2) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.19 Pain Relevance 0.46
Most of these channels are modulated by PKA and PKC mediated phosphorylation.
Regulation (modulated) of Phosphorylation (phosphorylation) of PKC associated with kinase c
3) Confidence 0.09 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.47 Pain Relevance 0.47

General Comments

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