INT18459

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2003
Negated 0
Speculated 2
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.42
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2c) plasma membrane (Adra2c) cytoplasm (Adra2c)
signal transducer activity (Adra2c)
Anatomy Link Frequency
GPI 1
MVD 1
Adra2c (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 19 99.96 Very High Very High Very High
antagonist 11 99.44 Very High Very High Very High
tolerance 2 97.84 Very High Very High Very High
Morphine 4 96.96 Very High Very High Very High
Clonidine 22 93.84 High High
tricyclic antidepressant 1 79.20 Quite High
Desipramine 1 76.16 Quite High
Opioid 6 75.00 Quite High
antidepressant 4 75.00 Quite High
Endep 1 74.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 96.44 Very High Very High Very High
Gallstones 2 89.24 High High
Hypothermia 1 70.56 Quite High
Diarrhoea 3 49.60 Quite Low
Depression 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of alpha 2-adrenoceptor agonists on gastrointestinal motility was assessed in normoglycaemic and streptozotocin-diabetic mice. 2.
Regulation (effect) of alpha 2-adrenoceptor associated with diabetes mellitus and agonist
1) Confidence 0.45 Published 1990 Journal J Auton Pharmacol Section Abstract Doc Link 1974257 Disease Relevance 0.17 Pain Relevance 0.25
The possible contribution of alpha2-adrenoceptor and nitric oxide (NO) pathways on the development of tolerance was assessed in GPI and MVD of cholestatic subjects. 3.
Spec (possible) Regulation (contribution) of alpha2-adrenoceptor in GPI associated with tolerance
2) Confidence 0.45 Published 2003 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 15084186 Disease Relevance 0.09 Pain Relevance 0.33
The effect of some alpha 2-adrenoceptor agonists and antagonists on gastrointestinal transit in mice: influence of morphine, castor oil and glucose.
Regulation (effect) of alpha 2-adrenoceptor associated with antagonist, agonist and morphine
3) Confidence 0.44 Published 1993 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 8094327 Disease Relevance 0 Pain Relevance 0.67
The results of the present study also demonstrate that serotonergic receptor function can influence alpha-2-adrenoreceptor mediated responses in the mouse forced swimming test.
Regulation (influence) of alpha-2-adrenoreceptor
4) Confidence 0.43 Published 1998 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 9716308 Disease Relevance 0 Pain Relevance 0.71
The effects of various alpha 2 adrenoceptor agonists on forced swimming-induced despair behaviour were studied in mice.
Regulation (effects) of alpha 2 adrenoceptor associated with agonist
5) Confidence 0.43 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3088633 Disease Relevance 0 Pain Relevance 0.61
The effects of alpha 2-adrenoceptor agonists on sulfobromophthalein (BSP) disposition in mice were studied.
Regulation (effects) of alpha 2-adrenoceptor associated with agonist
6) Confidence 0.43 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3609141 Disease Relevance 0.07 Pain Relevance 0.51
The possible contribution of alpha2-adrenoceptor and nitric oxide (NO) pathways on the development of tolerance was assessed in GPI and MVD of cholestatic subjects. 3.
Spec (possible) Regulation (contribution) of alpha2-adrenoceptor in MVD associated with tolerance
7) Confidence 0.15 Published 2003 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 15084186 Disease Relevance 0.09 Pain Relevance 0.33

General Comments

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