INT18461

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Context Info
Confidence 0.65
First Reported 1983
Last Reported 2003
Negated 3
Speculated 2
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 4.41
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pgc) extracellular region (Pgc) nucleolus (Pgc)
nucleus (Pgc)
Anatomy Link Frequency
lumen 8
macrophages 2
chief cell 2
vagus nerves 2
Pgc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 20 99.98 Very High Very High Very High
Nicotine 11 99.98 Very High Very High Very High
anesthesia 7 99.16 Very High Very High Very High
Intracerebroventricular 10 99.04 Very High Very High Very High
agonist 8 98.88 Very High Very High Very High
Parenteral administration 4 98.30 Very High Very High Very High
qutenza 34 97.12 Very High Very High Very High
peptic ulcer disease 8 87.96 High High
lidocaine 6 87.32 High High
antagonist 8 85.36 High High
Disease Link Frequency Relevance Heat
Nicotine Addiction 16 99.72 Very High Very High Very High
Duodenal Ulcer 9 97.12 Very High Very High Very High
Ulcers 19 92.44 High High
Disease 12 87.96 High High
Peptic Ulcer 3 78.44 Quite High
INFLAMMATION 5 77.88 Quite High
Gastric Motility Disorder 1 74.64 Quite High
Autoimmune Disease 1 73.12 Quite High
Stress 1 55.36 Quite High
Apoptosis 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Omeprazole, a selective inhibitor of gastric H+:K+-adenosintriphosphatase, blocked the increase in acid but not pepsinogen secretion induced by bethanechol.
Positive_regulation (increase) of Localization (secretion) of pepsinogen
1) Confidence 0.65 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9399975 Disease Relevance 0 Pain Relevance 0
When tested in animals pretreated with both omeprazole and physostigmine (a drug able to prevent the enzymatic breakdown of vagally released ACh through the blockade of acetylcholinesterase), 2-deoxy-D-glucose or electrical vagal stimulation significantly increased pepsinogen secretion without affecting acid secretion.
Positive_regulation (increased) of Localization (secretion) of pepsinogen
2) Confidence 0.65 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9399975 Disease Relevance 0 Pain Relevance 0.14
The present results indicate that the activation of muscarinic receptors by vagally released ACh is not sufficient by itself to stimulate pepsinogen secretion and that a facilitatory action mediated by acid secretion is necessary to allow an increment of peptic output in response to vagal cholinergic stimuli.
Neg (not) Positive_regulation (stimulate) of Localization (secretion) of pepsinogen
3) Confidence 0.65 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9399975 Disease Relevance 0 Pain Relevance 0.25
Following parenteral administration, the GABAB receptor agonists (-)-baclofen and 3-aminopropylphosphinic acid (3-APPA) caused a dose-dependent increase in basal pepsinogen secretion which was associated with a parallel increment in acid output.
Positive_regulation (caused) of Localization (secretion) of pepsinogen associated with agonist and parenteral administration
4) Confidence 0.58 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8788431 Disease Relevance 0 Pain Relevance 0.23
However, 2-deoxy-D-glucose or electrical vagal stimulation failed to increase either pepsinogen or acid secretion in omeprazole-pretreated rats.
Neg (failed) Positive_regulation (increase) of Localization (secretion) of pepsinogen
5) Confidence 0.57 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9399975 Disease Relevance 0 Pain Relevance 0.05
Omeprazole, a selective inhibitor of gastric H+:K+-adenosintriphosphatase, blocked the increase in acid but not pepsinogen secretion induced by bethanechol.
Neg (not) Positive_regulation (induced) of Localization (secretion) of pepsinogen
6) Confidence 0.47 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9399975 Disease Relevance 0 Pain Relevance 0
Administration of zinc acexamate resulted in an increase in the presence of pepsinogen at the mucosal level.
Positive_regulation (increase) of Localization (presence) of pepsinogen
7) Confidence 0.45 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1974292 Disease Relevance 0 Pain Relevance 0
Following parenteral administration, the GABAB receptor agonists (-)-baclofen and 3-aminopropylphosphinic acid (3-APPA) caused a dose-dependent increase in basal pepsinogen secretion which was associated with a parallel increment in acid output.
Positive_regulation (increase) of Localization (secretion) of pepsinogen associated with agonist and parenteral administration
8) Confidence 0.39 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8788431 Disease Relevance 0 Pain Relevance 0.23
The present results show that peripheral GABAB receptors mediate an excitatory effect on gastric pepsinogen secretion which totally depends on an increase in acid output.
Positive_regulation (depends) of Localization (secretion) of pepsinogen
9) Confidence 0.37 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8788431 Disease Relevance 0 Pain Relevance 0.16
When tested on rats undergoing bilateral cervical vagotomy, both (-)-baclofen and 3-APPA were still able to stimulate the basal pepsinogen and acid secretions, although at a lesser extent than in animals with intact vagus nerves.
Positive_regulation (stimulate) of Localization (secretions) of pepsinogen in vagus nerves
10) Confidence 0.34 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8788431 Disease Relevance 0 Pain Relevance 0.28
Central administration of cholecystokinin stimulates gastric pepsinogen secretion from anaesthetized rats.
Positive_regulation (stimulates) of Localization (secretion) of gastric pepsinogen associated with anesthesia and cholecystokinin
11) Confidence 0.14 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 7566655 Disease Relevance 0 Pain Relevance 0.33
Intracerebroventricular administration of CCK-8S was associated with a stimulation of gastric pepsinogen secretion from anaesthetized rats; similar effects were induced by CCK-8S given intravenously.
Positive_regulation (stimulation) of Localization (secretion) of gastric pepsinogen associated with intracerebroventricular
12) Confidence 0.09 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7566655 Disease Relevance 0 Pain Relevance 0.21
One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.
Positive_regulation (elevated) of Localization (secreted) of PG I in lumen associated with duodenal ulcer
13) Confidence 0.09 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.71 Pain Relevance 0.16
One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.
Spec (appearing) Positive_regulation (appearing) of Localization (secreted) of serum pepsinogen I in lumen associated with duodenal ulcer
14) Confidence 0.09 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.72 Pain Relevance 0.16
One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.
Positive_regulation (elevated) of Localization (secreted) of serum pepsinogen I in lumen associated with duodenal ulcer
15) Confidence 0.09 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.71 Pain Relevance 0.16
One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.
Spec (appearing) Positive_regulation (appearing) of Localization (secreted) of PG I in lumen associated with duodenal ulcer
16) Confidence 0.09 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.72 Pain Relevance 0.16
In anaesthetized rats, i.v. injection of CCK-8S or gastrin-I increased both pepsinogen and acid secretion.
Positive_regulation (increased) of Localization (secretion) of pepsinogen associated with cholecystokinin
17) Confidence 0.07 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408253 Disease Relevance 0 Pain Relevance 0.52
Smoking and nicotine stimulate pepsinogen secretion also by increasing chief cell number or with an enhancement of their secretory capacity.
Positive_regulation (stimulate) of Localization (secretion) of pepsinogen in chief cell associated with nicotine addiction and nicotine
18) Confidence 0.04 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.25 Pain Relevance 0.38
However, the secretion of 6-keto PG F1 alpha was enhanced by 40 and 29% from macrophages preincubated with 10 microM curcumin or capsaicin, respectively, as compared to those produced by control cells.
Positive_regulation (enhanced) of Localization (secretion) of PG F1 alpha in macrophages associated with qutenza
19) Confidence 0.01 Published 1997 Journal Lipids Section Abstract Doc Link 9397403 Disease Relevance 0.29 Pain Relevance 0.56

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