INT18462

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 29
Total Number 29
Disease Relevance 22.55
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pgc) extracellular region (Pgc) nucleolus (Pgc)
nucleus (Pgc)
Anatomy Link Frequency
lumen 2
plasma 1
muscle tissues 1
vagus nerves 1
PGC 1
Pgc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 36 99.66 Very High Very High Very High
peptic ulcer disease 22 97.52 Very High Very High Very High
qutenza 13 95.60 Very High Very High Very High
antagonist 6 89.60 High High
Intracerebroventricular 2 87.84 High High
agonist 4 86.04 High High
alcohol 1 83.88 Quite High
aspirin 3 80.96 Quite High
lidocaine 3 79.52 Quite High
Parenteral administration 2 75.44 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 46 100.00 Very High Very High Very High
Duodenal Ulcer 59 99.96 Very High Very High Very High
Syndrome 20 99.96 Very High Very High Very High
Multiple Endocrine Neoplasia Type 1 30 99.78 Very High Very High Very High
Ulcers 89 99.68 Very High Very High Very High
Natriuresis 12 99.62 Very High Very High Very High
Diabetes Mellitus 28 99.36 Very High Very High Very High
Infection 18 99.18 Very High Very High Very High
Gastric Motility Disorder 10 98.72 Very High Very High Very High
Peptic Ulcer 46 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, 2-deoxy-D-glucose or electrical vagal stimulation failed to increase either pepsinogen or acid secretion in omeprazole-pretreated rats.
Neg (failed) Positive_regulation (increase) of pepsinogen
1) Confidence 0.57 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9399975 Disease Relevance 0 Pain Relevance 0.05
About half of the patients with duodenal ulcer have elevated plasma pepsinogen I.
Positive_regulation (elevated) of pepsinogen in plasma associated with duodenal ulcer
2) Confidence 0.53 Published 1984 Journal Clin Gastroenterol Section Abstract Doc Link 6378441 Disease Relevance 1.94 Pain Relevance 0.20
In addition, the (-)-baclofen-induced increases in both pepsinogen and acid output, were fully prevented by omeprazole or cimetidine, partly reduced by atropine and unaffected by pretreatment with capsaicin.
Positive_regulation (increases) of pepsinogen associated with qutenza
3) Confidence 0.51 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8788431 Disease Relevance 0 Pain Relevance 0.30
Administration of zinc acexamate resulted in an increase in the presence of pepsinogen at the mucosal level.
Positive_regulation (increase) of pepsinogen
4) Confidence 0.49 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1974292 Disease Relevance 0 Pain Relevance 0
The cGMP production and pGC activity in response to CNP in gastric muscle tissues were significantly potentiated in STZ-induced diabetic rats.
Positive_regulation (potentiated) of pGC in muscle tissues associated with diabetes mellitus
5) Confidence 0.43 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19267196 Disease Relevance 1.26 Pain Relevance 0
This high hospital mortality ratio and unsuccessful outcames after PGC can be attributed to the poor condition of patients and failure to control sepsis [1,8].
Positive_regulation (attributed) of PGC associated with sepsis and stomach cancer
6) Confidence 0.41 Published 2008 Journal World J Emerg Surg Section Body Doc Link PMC2397385 Disease Relevance 1.34 Pain Relevance 0
RESULTS: Of the subjects, 90% (nine of 10) with elevated PG1 were seropositive for Hp, compared to only 31% (17 of 55) of those with normal PG1 levels (p < 0.001).
Positive_regulation (elevated) of PG1
7) Confidence 0.40 Published 2000 Journal Am. J. Gastroenterol. Section Body Doc Link 10763942 Disease Relevance 0.27 Pain Relevance 0
In 1979, Rotter et al. reported two pedigrees in which elevated PG1 levels and duodenal ulcers were prevalent.
Positive_regulation (elevated) of PG1 associated with duodenal ulcer
8) Confidence 0.40 Published 2000 Journal Am. J. Gastroenterol. Section Abstract Doc Link 10763942 Disease Relevance 0.89 Pain Relevance 0.08
We tested serum from one of the original pedigrees for Hp antibodies to determine whether Hp infection could explain the ulcers and elevated PG1 levels.
Positive_regulation (elevated) of PG1 associated with ulcers and infection
9) Confidence 0.40 Published 2000 Journal Am. J. Gastroenterol. Section Abstract Doc Link 10763942 Disease Relevance 1.26 Pain Relevance 0.09
They proposed autosomal dominant inheritance of elevated PG1 and suggested that it was a risk factor for duodenal ulcer disease.
Positive_regulation (elevated) of PG1 associated with duodenal ulcer
10) Confidence 0.40 Published 2000 Journal Am. J. Gastroenterol. Section Abstract Doc Link 10763942 Disease Relevance 0.96 Pain Relevance 0.09
CONCLUSIONS: The etiology of elevated PG1 levels in this pedigree is more likely due to Helicobacter pylori infection than to a genetic predisposition.


Positive_regulation (elevated) of PG1
11) Confidence 0.40 Published 2000 Journal Am. J. Gastroenterol. Section Body Doc Link 10763942 Disease Relevance 0.21 Pain Relevance 0
The prevalence of Hp-seropositivity and elevated PG1 declined in parallel in each successive generation.
Positive_regulation (elevated) of PG1
12) Confidence 0.40 Published 2000 Journal Am. J. Gastroenterol. Section Body Doc Link 10763942 Disease Relevance 0.23 Pain Relevance 0
When tested on rats undergoing bilateral cervical vagotomy, both (-)-baclofen and 3-APPA were still able to stimulate the basal pepsinogen and acid secretions, although at a lesser extent than in animals with intact vagus nerves.
Positive_regulation (stimulate) of pepsinogen in vagus nerves
13) Confidence 0.37 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8788431 Disease Relevance 0 Pain Relevance 0.28
The results suggest that natriuretic peptide-dependent pGC-cGMP signal is upregulated and may contribute to diabetic gastroparesis in STZ-induced diabetic rats.
Positive_regulation (upregulated) of pGC associated with natriuresis, diabetes mellitus and gastric motility disorder
14) Confidence 0.35 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19267196 Disease Relevance 1.25 Pain Relevance 0
There was a daywise increase in the number of PGC in all groups.
Positive_regulation (increase) of PGC in PGC
15) Confidence 0.27 Published 2004 Journal Biol. Reprod. Section Abstract Doc Link 15286041 Disease Relevance 0 Pain Relevance 0.07
One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.
Positive_regulation (elevated) of PG I in lumen associated with duodenal ulcer
16) Confidence 0.12 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.69 Pain Relevance 0.16
One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.
Positive_regulation (elevated) of serum pepsinogen I in lumen associated with duodenal ulcer
17) Confidence 0.12 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.69 Pain Relevance 0.16
Patients with a cagA-positive genotype showed a significant increase in anti-cagA antibodies and also had significantly increased circulating levels of pepsinogen C.
Positive_regulation (increased) of pepsinogen
18) Confidence 0.08 Published 1998 Journal Am. J. Gastroenterol. Section Body Doc Link 9468248 Disease Relevance 0.08 Pain Relevance 0
After pretreatment with omeprazole, both CCK-8S and gastrin-I failed to stimulate acid secretion, while they increased pepsinogen output.
Neg (failed) Positive_regulation (increased) of pepsinogen associated with cholecystokinin
19) Confidence 0.07 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408253 Disease Relevance 0 Pain Relevance 0.59
In anaesthetized rats, i.v. injection of CCK-8S or gastrin-I increased both pepsinogen and acid secretion.
Positive_regulation (increased) of pepsinogen associated with cholecystokinin
20) Confidence 0.07 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408253 Disease Relevance 0 Pain Relevance 0.52

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