INT184624

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.87
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
skeletal muscle 1
saliva 1
telomere 1
intervertebral disc 1
respiratory 1
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 47 93.68 High High
Inflammation 8 90.48 High High
Pain 15 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
backache 12 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
cocaine 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Renal Failure 25 100.00 Very High Very High Very High
Cancer 275 99.96 Very High Very High Very High
Toxicity 7 99.88 Very High Very High Very High
Rhabdomyolysis 100 99.48 Very High Very High Very High
Infection 22 99.30 Very High Very High Very High
Death 3 99.28 Very High Very High Very High
Dyspnea 3 99.14 Very High Very High Very High
Papillomavirus Infection 55 99.10 Very High Very High Very High
Respiratory Distress 1 98.96 Very High Very High Very High
Aging 134 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
p16INK4A Immunohistochemical localisation in human intervertebral disc tissue
Localization (localisation) of p16INK4A in intervertebral disc
1) Confidence 0.74 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.06 Pain Relevance 0
Regulation of INK4a/ARF locus by CBX7 also needs further confirmation in cancer cells.
Localization (locus) of INK4a associated with cancer
2) Confidence 0.73 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.19 Pain Relevance 0
Regulation of INK4a/ARF locus by CBX7 also needs further confirmation in cancer cells.
Localization (locus) of ARF associated with cancer
3) Confidence 0.73 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.19 Pain Relevance 0
The effect of prognostic factors on an occurrence of any selected adverse events (AEs; neutropenia, thrombocytopenia, reduced haemoglobin, infection requiring hospitalisation or intravenous antibiotics, respiratory distress syndrome, dyspnea, death, or life-threatening toxicity) and methylation of p16 and RASSF1A were assessed.


Localization (methylation) of p16 in respiratory associated with neutropenia, toxicity, thrombocytopenia, dyspnea, respiratory distress, death and infection
4) Confidence 0.67 Published 2011 Journal Journal of Cancer Section Body Doc Link PMC3020361 Disease Relevance 1.03 Pain Relevance 0
In cervical carcinogenesis triggered by high-risk type HPV infection, E7 inhibits Rb, resulting in the release of active host E2F-1, which positively regulates host p14ARF.
Localization (release) of p14ARF associated with papillomavirus infection and infection
5) Confidence 0.56 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.32 Pain Relevance 0
Indeed, in vitro treatment of chondrocytes with oxygen peroxide (H2O2) used as source of ROS, resulted in p53/p21Waf1/Cip1, p16ink4a accumulation and telomere attrition which are both hallmarks of cellular senescence [12, 28, 29].
Localization (accumulation) of p16ink4a in telomere associated with aging
6) Confidence 0.26 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.36 Pain Relevance 0.25
And, in head and neck cancers, methylation of p16, DAPK and MGMT have been detected in saliva (Rosas et al. 2001).


Localization (methylation) of p16 in saliva associated with cancer
7) Confidence 0.19 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717819 Disease Relevance 0.86 Pain Relevance 0
Both ARF and the increased release of creatinine from skeletal muscle increase the serum concentrations of urea nitrogen and creatinine.
Localization (release) of ARF in skeletal muscle associated with acute renal failure
8) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1175909 Disease Relevance 0.86 Pain Relevance 0

General Comments

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