INT184651

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.46
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RRM1) nucleoplasm (RRM1) small molecule metabolic process (RRM1)
oxidoreductase activity (RRM1) cytoplasm (RRM1)
Anatomy Link Frequency
neuron 1
RRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 89.86 High High
cytokine 42 70.24 Quite High
Multiple sclerosis 7 53.52 Quite High
Central nervous system 21 29.44 Quite Low
Peripheral nervous system 8 28.80 Quite Low
imagery 27 5.00 Very Low Very Low Very Low
Pain 21 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Nerve growth factor 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Non-small-cell Lung Cancer 62 99.28 Very High Very High Very High
Apoptosis 32 97.84 Very High Very High Very High
Cancer 219 97.36 Very High Very High Very High
Weight Loss 6 96.48 Very High Very High Very High
Nicotine Addiction 63 95.76 Very High Very High Very High
Cold Sores 367 94.36 High High
Disease 56 94.36 High High
Toxicity 42 92.40 High High
Death 15 84.40 Quite High
Injury 3 76.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Being a major target of gemcitabine, RR has been widely investigated in cohorts of NSCLC patients treated with the drug, with specific attention for the RRM1 subunit.76–79 Most of the studies showed that RRM1 mRNA expression was associated with significantly longer overall survival in patients who received a gemcitabine-based doublet both in the neoadjuvant and palliative setting,76–79 while it represented a prognostic factor for decreased survival for patients who underwent surgery alone.80 In addition, also RRM1 polymorphisms have been correlated with outcome in NSCLC patients treated with gemcitabine,81 despite the lack of a clear association between different haplotypes and RRM1 expression.81,82 These findings led investigators to perform a randomized phase II trial aimed at customizing treatment based on ERCC1 – a predictor for platinum compounds activity83 – and RRM1 expression in 85 chemonaive NSCLC patients with advanced disease84 Based on tumor expression of these two biomarkers, doublets including carboplatin, gemcitabine, vinorelbine and docetaxel were selected.
Gene_expression (expression) of RRM1 associated with cancer, non-small-cell lung cancer and palliative
1) Confidence 0.48 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886326 Disease Relevance 0.58 Pain Relevance 0.09
Additionally, molecular markers such as p53 and ras mutations, and expression of ERCC1, beta-tubulin III and RRM1, have been found to influence treatment outcome 5,13-15.
Gene_expression (expression) of RRM1
2) Confidence 0.42 Published 2011 Journal Journal of Cancer Section Body Doc Link PMC3020361 Disease Relevance 1.88 Pain Relevance 0
One example of RR(n) and TTot(n) series of a patient is depicted in Fig. 6.
Gene_expression (example) of RR
3) Confidence 0.39 Published 2010 Journal Ann Biomed Eng Section Body Doc Link PMC2900596 Disease Relevance 0 Pain Relevance 0
We then assert axiomatically that r1 adjacent_to r2 implies not r1 overlap r2
Gene_expression (adjacent_to) of r1
4) Confidence 0.06 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175958 Disease Relevance 0 Pain Relevance 0
r, r1, ... to range over three-dimensional spatial regions;
Gene_expression (regions) of r1
5) Confidence 0.06 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175958 Disease Relevance 0 Pain Relevance 0
RR, release increased levels of VEGF and FKN that protect uninfected neurons from apoptosis both through neuron-neuron and bidirectional neuron-microglia communications [77].
Gene_expression (levels) of RR in neuron associated with apoptosis
6) Confidence 0.05 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.01 Pain Relevance 0.06

General Comments

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