INT184674

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.14
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prrx2) DNA binding (Prrx2)
Anatomy Link Frequency
reproductive organs 1
Prrx2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 97.44 Very High Very High Very High
Hippocampus 96 89.12 High High
Inflammation 10 41.12 Quite Low
Central nervous system 10 32.56 Quite Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 22 98.68 Very High Very High Very High
Aging 200 97.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 95.80 Very High Very High Very High
Infection 6 94.92 High High
Sprains And Strains 248 94.48 High High
Death 8 94.24 High High
Cancer 8 92.64 High High
Shock 12 89.80 High High
Stress 6 87.88 High High
Cognitive Disorder 2 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The senescence-prone mice also demonstrated differential expression of some genes known to be involved in human diseases: these include transthyretin (Ttr) and Kcnq2, both of which show decreased levels of expression in S8 and S10.
Negative_regulation (decreased) of S8 associated with aging and disease
1) Confidence 0.23 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.50 Pain Relevance 0.04
Finally, an analysis of litter size also showed a significant decrease in fecundity in both S8 and S10 mice as compared with SR, consistent with accelerated aging of the reproductive organs (data not shown) [33].
Negative_regulation (decrease) of S8 in reproductive organs associated with aging
2) Confidence 0.20 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.65 Pain Relevance 0.10

General Comments

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