INT184677

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.19
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Spaca4) plasma membrane (Spaca4) molecular_function (Spaca4)
cellular_component (Spaca4) biological_process (Spaca4)
Anatomy Link Frequency
cortex 1
hippocampus 1
Spaca4 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 108 100.00 Very High Very High Very High
medulla 51 100.00 Very High Very High Very High
anesthesia 2 95.76 Very High Very High Very High
Glutamate 9 67.68 Quite High
Central nervous system 8 51.84 Quite High
Neuronal nitric oxide synthase 3 50.00 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 175 100.00 Very High Very High Very High
Cognitive Disorder 10 100.00 Very High Very High Very High
Cancer 4 99.84 Very High Very High Very High
Sprains And Strains 130 99.56 Very High Very High Very High
Death 19 98.20 Very High Very High Very High
Infection 3 97.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.08 Very High Very High Very High
Alzheimer's Dementia 24 95.48 Very High Very High Very High
Stress 24 93.04 High High
Neurodegenerative Disease 9 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
the cognitive decline in the aged SAMP8, since a reduction of A?
Negative_regulation (decline) of SAMP8 associated with cognitive disorder
1) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.78 Pain Relevance 0.13
By contrast, our data show a marked decrease in nNOS activity in the hippocampus at 8 months of age, i.e. well before aging, only in SAMP8.
Negative_regulation (decrease) of SAMP8 in hippocampus associated with aging and hippocampus
2) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.39 Pain Relevance 0.28
In SAMP8, nNOS activity increased (P < 0.01) in the cortex and the brainstem from 2 to 8 months, and then decreased (P < 0.01) in 12-vs 2 or 8 month-old mice.
Negative_regulation (decreased) of SAMP8 in cortex associated with medulla
3) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.05 Pain Relevance 0.40
Whereas the single greatest cause of death in the SAMR1 strain was cancer (consistent with the original AKR/J strain from which the SAM strains were developed), the SAMP10 and SAMP8 mice showed a decrease in cancer-related deaths and an increase in death due to infection or a wasting syndrome consistent with neurological dysfunction.
Negative_regulation (decrease) of SAMP10 associated with anesthesia, cancer, acquired immune deficiency syndrome or hiv infection, sprains and strains, infection and death
4) Confidence 0.01 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.97 Pain Relevance 0.10

General Comments

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