INT184683

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 7.90
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prrx2) DNA binding (Prrx2)
Anatomy Link Frequency
retina 4
hippocampus 4
Prrx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 672 100.00 Very High Very High Very High
opioid receptor 14 90.72 High High
Neurobehavioral 14 63.04 Quite High
chemokine 42 59.96 Quite High
depression 14 50.24 Quite High
Inflammation 70 40.32 Quite Low
Central nervous system 70 31.76 Quite Low
gABA 14 11.00 Low Low
anesthesia 28 5.00 Very Low Very Low Very Low
Inflammatory response 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 1400 99.08 Very High Very High Very High
Disease 154 98.28 Very High Very High Very High
Repression 14 96.60 Very High Very High Very High
Sprains And Strains 1736 94.48 High High
Hutchinson-gilford Progeria Syndrome 14 93.04 High High
Shock 84 89.00 High High
Stress 42 87.08 High High
Age-related Macular Degeneration 14 74.00 Quite High
Ganglion Cysts 14 71.24 Quite High
Frailty 28 55.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This analysis revealed an interesting region on chromosome 4 of S8 mice harboring multiple genes that were more highly expressed in S8 than SR1 (Figure 5).
Gene_expression (expressed) of S8
1) Confidence 0.37 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.26 Pain Relevance 0.09
A gene was considered differentially expressed between conditions (that is, old S8 retina versus young S8 retina) only if it met the above criteria in more than 70% of the pairwise comparisons (3/4 or 4/4 comparisons), and carried a statistically significant absolute call of 'Present' (P) or 'Marginal' (M) in at least one sample (see Materials and methods for more detail).
Gene_expression (expressed) of S8 in retina
2) Confidence 0.36 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.42 Pain Relevance 0
The other transcript studied in this manner, Iap had a two- to five-fold higher expression level in both S8 and S10 relative to SR1 mice in the hippocampus and retina.
Gene_expression (expression) of S8 in hippocampus associated with hippocampus
3) Confidence 0.36 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0 Pain Relevance 0.24
The senescence-prone mice also demonstrated differential expression of some genes known to be involved in human diseases: these include transthyretin (Ttr) and Kcnq2, both of which show decreased levels of expression in S8 and S10.
Gene_expression (expression) of S8 associated with aging and disease
4) Confidence 0.36 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.48 Pain Relevance 0.04
The RNA levels for six genes in retina or hippocampus were higher in S8 than SR1, representing 21% (6/29) of the S8-SR1 specific hippocampal gene expression differences and 26% (5/19) of the retinal differences.
Gene_expression (expression) of S8 in hippocampus associated with hippocampus
5) Confidence 0.36 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.23 Pain Relevance 0.09
This analysis revealed an interesting region on chromosome 4 of S8 mice harboring multiple genes that were more highly expressed in S8 than SR1 (Figure 5).
Gene_expression (expressed) of S8
6) Confidence 0.32 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.25 Pain Relevance 0.09
A gene was considered differentially expressed between conditions (that is, old S8 retina versus young S8 retina) only if it met the above criteria in more than 70% of the pairwise comparisons (3/4 or 4/4 comparisons), and carried a statistically significant absolute call of 'Present' (P) or 'Marginal' (M) in at least one sample (see Materials and methods for more detail).
Gene_expression (expressed) of S8 in retina
7) Confidence 0.32 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.47 Pain Relevance 0
These genes are more highly expressed by a factor of 1.7 to 7.4 in S8 relative to SR1 mice.
Gene_expression (expressed) of S8
8) Confidence 0.32 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.30 Pain Relevance 0.15
To explore the events involved in the molecular senescence of the mammalian brain, we established and aged the colonies, verified the phenotypes, and performed gene-expression analysis of the retina and hippocampus in S8 and S10 mice using oligonucleotide microarrays [31].
Gene_expression (expression) of S8 in retina associated with aging and hippocampus
9) Confidence 0.32 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.45 Pain Relevance 0.11
The RNA levels for six genes in retina or hippocampus were higher in S8 than SR1, representing 21% (6/29) of the S8-SR1 specific hippocampal gene expression differences and 26% (5/19) of the retinal differences.
Gene_expression (higher) of S8 in hippocampus associated with hippocampus
10) Confidence 0.32 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.24 Pain Relevance 0.09
A cluster of genes on chromosome 4, including Ccl19, is differentially expressed between S8 and SR1 mice
Gene_expression (expressed) of S8
11) Confidence 0.32 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.27 Pain Relevance 0.14
In the case of S8 and S10, Iap expression was elevated two- to five-fold in young mice relative to SR1, and remained elevated throughout the life span of the mouse.
Gene_expression (expression) of S8
12) Confidence 0.18 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.07 Pain Relevance 0.11
The other transcript studied in this manner, Iap had a two- to five-fold higher expression level in both S8 and S10 relative to SR1 mice in the hippocampus and retina.
Gene_expression (expression) of S8 in retina associated with hippocampus
13) Confidence 0.12 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0 Pain Relevance 0.24
To explore the events involved in the molecular senescence of the mammalian brain, we established and aged the colonies, verified the phenotypes, and performed gene-expression analysis of the retina and hippocampus in S8 and S10 mice using oligonucleotide microarrays [31].
Gene_expression (expression) of S8 in hippocampus associated with aging and hippocampus
14) Confidence 0.11 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.45 Pain Relevance 0.11

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