INT184690

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.97
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
blood vessels 1
bursa 1
neurons 1
hind limbs 1
connective tissue 1
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 47 99.26 Very High Very High Very High
Inflammation 32 83.12 Quite High
cytokine 20 82.08 Quite High
Central nervous system 5 74.12 Quite High
Dismenorea 1 52.32 Quite High
Hippocampus 48 41.92 Quite Low
Pain 9 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 99.80 Very High Very High Very High
Cv Unclassified Under Development 46 99.26 Very High Very High Very High
Disease 23 98.52 Very High Very High Very High
Cancer 28 88.04 High High
Frailty 2 87.04 High High
Targeted Disruption 3 86.00 High High
Sprains And Strains 127 84.80 Quite High
INFLAMMATION 35 83.12 Quite High
Necrosis 8 77.76 Quite High
Aging 100 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, FGF1 has been shown to protect neurons from excitotoxic stress, and low FGF1 mRNA levels have been implicated in Alzheimer's disease [43-46].
Transcription (levels) of FGF1 in neurons associated with stress and disease
1) Confidence 0.51 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.77 Pain Relevance 0.07
Specifically, it was demonstrated both in animal models [20] and in clinical trials [21] that muscular ischemia is associated with up-regulation of FGF gene transcription, suggesting that this is part of the endogenous pro-angiogenic response to ischemia.
Transcription (transcription) of FGF associated with ischemia
2) Confidence 0.34 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.51 Pain Relevance 0.20
It has been shown that certain regulatory genes are expressed differently in the early developing forelimb and hindlimb, with a survey of Wnt gene expression patterns in the limb bud showing differences in transcript distribution between forelimb and hindlimb [29] and a genome wide analysis of transcripts differentially expressed in the fore and hind limbs demonstrating differences in the use of Fgf, Hedgehog and BMP family signalling molecules [32].
Transcription (expressed) of Fgf in hind limbs
3) Confidence 0.24 Published 2010 Journal Bone Section Body Doc Link PMC2860222 Disease Relevance 0.05 Pain Relevance 0.05
However, FGF-2 mRNA levels were low throughout the tissue – the ratio of FGF-2 mRNA to GAPDH mRNA was about 10 times lower than the ratio of BMP mRNA to GAPDH mRNA- and was not preferentially localized within the bursa.
Transcription (levels) of FGF in bursa
4) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.24 Pain Relevance 0.08
As examples of alternative tissue growth factors, fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF) mRNA was also present and helps to explain the proliferation of the bursa into granulation tissue, with loose connective tissue and blood vessels amply present.
Transcription (present) of FGF in blood vessels
5) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.20 Pain Relevance 0.07
As examples of alternative tissue growth factors, fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF) mRNA was also present and helps to explain the proliferation of the bursa into granulation tissue, with loose connective tissue and blood vessels amply present.
Transcription (present) of FGF in connective tissue
6) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.20 Pain Relevance 0.07

General Comments

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