INT184693

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.42
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xbp1) DNA binding (Xbp1)
Xbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 96 71.12 Quite High
Inflammation 10 54.72 Quite High
Central nervous system 10 46.16 Quite Low
gABA 14 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Migraine 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 69 100.00 Very High Very High Very High
Shock 12 100.00 Very High Very High Very High
Aging 200 99.44 Very High Very High Very High
Sprains And Strains 248 98.06 Very High Very High Very High
Disease 22 90.80 High High
Manic Depressive Disorder 57 64.52 Quite High
INFLAMMATION 14 54.72 Quite High
Repression 2 42.64 Quite Low
Depression 11 5.00 Very Low Very Low Very Low
Oxidative Phosphorylation Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The two strains demonstrating accelerated aging, S8 and S10, shared many differences relative to SR1, including increased expression levels of stress-response genes such as those for the heat-shock proteins Hsp70-1 and Hspa5, and for X-box binding protein 1 (Xbp1).
Positive_regulation (increased) of Gene_expression (expression) of X-box binding protein 1 associated with stress, aging, shock and sprains and strains
1) Confidence 0.47 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.81 Pain Relevance 0.06
The two strains demonstrating accelerated aging, S8 and S10, shared many differences relative to SR1, including increased expression levels of stress-response genes such as those for the heat-shock proteins Hsp70-1 and Hspa5, and for X-box binding protein 1 (Xbp1).
Positive_regulation (increased) of Gene_expression (expression) of Xbp1 associated with stress, aging, shock and sprains and strains
2) Confidence 0.47 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.81 Pain Relevance 0.06
We therefore considered the possibility that the addition of valproate to XBP-1 expression can enhance luciferease activity.
Positive_regulation (enhance) of Gene_expression (expression) of XBP-1
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.17 Pain Relevance 0
Consistent with previous results, this activation can be enhanced by co-transfection of the transcription factor XBP-1.
Positive_regulation (enhanced) of Gene_expression (transfection) of XBP-1
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.31 Pain Relevance 0
Consistent with previous results, this activation can be enhanced by co-transfection of the transcription factor XBP-1.
Positive_regulation (transfection) of Gene_expression (transfection) of XBP-1
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.31 Pain Relevance 0

General Comments

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